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Literature summary extracted from

  • Herman, C.; Prakash, S.; Lu, C.Z.; Matouschek, A.; Gross, C.A.
    Lack of a robust unfoldase activity confers a unique level of substrate specificity to the universal AAA protease FtsH (2003), Mol. Cell, 11, 659-669.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.24.B17 membrane integral, active site facing the cytoplasm Escherichia coli 16020
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.24.B17 Zn2+ metalloprotease Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.B17 protein + H2O Escherichia coli housekeeping function, because the enzyme lacks a robust unfoldase activity, it is able to use the substrate protein folding state as a criterion for degradation peptides
-
 ?
3.4.24.B17 protein SecY + H2O Escherichia coli uncomplexed subunit of the protein translocase ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.B17 Escherichia coli
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
3.4.24.B17 proteolytic degradation of proteins mechanism, reaction only occurs with protein substrates of low intrinsic thermodynamic stability, sequential degradation from the tail Escherichia coli
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.B17 barnase tagged with SsrA tail + H2O tail specific degradation Escherichia coli ?
-
 ?
3.4.24.B17 dihydrofolate reductase tagged with SsrA tail + H2O tail specific degradation Escherichia coli ?
-
 ?
3.4.24.B17 additional information no activity with GFP-tagged proteins Escherichia coli ?
-
 ?
3.4.24.B17 protein + H2O enzyme recognizes nonpolar tails, overview, degrades integral and cytoplasmic proteins Escherichia coli peptides
-
 ?
3.4.24.B17 protein + H2O housekeeping function, because the enzyme lacks a robust unfoldase activity, it is able to use the substrate protein folding state as a criterion for degradation Escherichia coli peptides
-
 ?
3.4.24.B17 protein P22 Arc repressor tagged with 108 motif tail + H2O tail specific degradation Escherichia coli ?
-
 ?
3.4.24.B17 protein P22 Arc repressor tagged with SsrA tail + H2O tail specific degradation Escherichia coli ?
-
 ?
3.4.24.B17 protein SecY + H2O uncomplexed subunit of the protein translocase Escherichia coli ?
-
 ?
3.4.24.B17 protein sigma32 + H2O regulatory protein Escherichia coli ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.B17 FtsH
-
 Escherichia coli
3.4.24.B17 M41.001 Merops-ID Escherichia coli

Cofactor

EC Number Cofactor Comment Organism Structure
3.4.24.B17 ATP dependent on, enzyme is the only essential ATP-dependent protease in Escherichia coli Escherichia coli