Literature summary extracted from

Dogne, J.M.; Wouters, J.; Rolin, S.; Michaux, C.; Pochet, L.; Durant, F.; Delarge, J.; Masereel, B.
Design, synthesis and biological evaluation of a sulfonylcyanoguanidine as thromboxane A2 receptor antagonist and thromboxane synthase inhibitor (2001), J. Pharm. Pharmacol., 53, 669-680.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
5.3.99.5	furegrelate	0.01 mM, 68% inhibition	Homo sapiens
5.3.99.5	N-isopropyl-N'-[2-(3'-methylphenylamino)-5-nitrobenzenesulfonyl]urea	0.001 mM, 95% inhibition	Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
5.3.99.5	(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate	Homo sapiens	-	(5Z,13E)-(15S)-9alpha,11alpha-epoxy-15-hydroxythromboxa-5,13-dienoate	i.e. TXA2	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
5.3.99.5	Homo sapiens	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
5.3.99.5	(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate	-	Homo sapiens	(5Z,13E)-(15S)-9alpha,11alpha-epoxy-15-hydroxythromboxa-5,13-dienoate	i.e. TXA2	?

Synonyms

EC Number	Synonyms	Comment	Organism
5.3.99.5	TXA2 synthase	-	Homo sapiens

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Release 2023.1 (January 2023)