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Literature summary extracted from

  • Trapani, S.; Linss, J.; Goldenberg, S.; Fischer, H.; Craievich, A.F.; Oliva, G.
    Crystal structure of the dimeric phosphoenolpyruvate carboxykinase (PEPCK) from Trypanosoma cruzi at 2 A resolution (2001), J. Mol. Biol., 313, 1059-1072.
    View publication on PubMed

Application

EC Number Application Comment Organism
4.1.1.49 medicine Trypanosoma cruzi is the causative agent of Chagas' disease, enzyme is a good target for the development of new anti-chagasic drugs Trypanosoma cruzi

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.1.1.49 expressed in Escherichia coli Trypanosoma cruzi

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
4.1.1.49 sitting drop vapour diffusion, primitive orthorhombic crystals, space group P2(1)2(1)2(1), a : 65.97 A, b : 107.61 A, c : 179.08 A Trypanosoma cruzi

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.1.1.49 ATP + oxaloacetate Trypanosoma cruzi
-
 ADP + phosphoenolpyruvate + CO2
-
 r

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.49 Trypanosoma cruzi P51058
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.1.1.49
-
 Trypanosoma cruzi

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.49 ATP + oxaloacetate
-
 Trypanosoma cruzi ADP + phosphoenolpyruvate + CO2
-
 r

Subunits

EC Number Subunits Comment Organism
4.1.1.49 dimer
-
 Trypanosoma cruzi

Synonyms

EC Number Synonyms Comment Organism
4.1.1.49 ATP:oxaloacetate carboxylyase (transphosphorylating)
-
 Trypanosoma cruzi
4.1.1.49 PEPCK
-
 Trypanosoma cruzi
4.1.1.49 phosphoenolpyruvate carboxykinase
-
 Trypanosoma cruzi