EC Number | Cloned (Comment) | Organism |
---|---|---|
3.4.24.B4 | overexpression in Escherichia coli BL21(DE3) | Mus musculus |
EC Number | Crystallization (Comment) | Organism |
---|---|---|
3.4.24.B4 | enzyme complexed with a hydroxamate inhibitor, hanging-drop vapour diffusion method, 17 mg/ml protein in 10 mM HEPES, pH 7.5, with ammonium sufate to saturation, 18°C, 60 days, X-ray diffraction structure determination at 2.0 A resolution, and analysis | Mus musculus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.4.24.B4 | hydroxamate inhibitor RS-113456 | a diphenyl ether sulfon compound, complexing of the enzyme via His205 and Glu202 | Mus musculus |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
3.4.24.B4 | Zn2+ | His201, His211, and His 205 are involved in metal ion binding, geometry from crystal structure | Mus musculus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.24.B4 | protein + H2O | Mus musculus | - |
peptides | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.24.B4 | Mus musculus | P33435 | precursor | - |
EC Number | Purification (Comment) | Organism |
---|---|---|
3.4.24.B4 | recombinant from Escherichia coli | Mus musculus |
EC Number | Reaction | Comment | Organism | Reaction ID |
---|---|---|---|---|
3.4.24.B4 | proteolytic degradation of proteins | structure of the catalytic domain | Mus musculus |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.4.24.B4 | chondrocyte | hypertrophic, enzyme expression during bone development | Mus musculus | - |
3.4.24.B4 | osteoblast | enzyme expression during bone development | Mus musculus | - |
3.4.24.B4 | periosteum | enzyme expression during bone development | Mus musculus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.24.B4 | aggrecan + H2O | - |
Mus musculus | ? | - |
? | |
3.4.24.B4 | cartilage + H2O | - |
Mus musculus | ? | - |
? | |
3.4.24.B4 | collagen type II + H2O | - |
Mus musculus | ? | - |
? | |
3.4.24.B4 | Fibronectin + H2O | - |
Mus musculus | ? | - |
? | |
3.4.24.B4 | protein + H2O | - |
Mus musculus | peptides | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.4.24.B4 | M10.013 | Merops-ID | Mus musculus |
3.4.24.B4 | matrix metalloproteinase-13 | - |
Mus musculus |
3.4.24.B4 | MMP-13 | - |
Mus musculus |
3.4.24.B4 | MMP13 | - |
Mus musculus |