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Literature summary extracted from

  • Reshetnikova, L.; Moor, N.; Lavrik, O.; Vassylyev, D.G.
    Crystal structures of phenylalanyl-tRNA synthetase complexed with phenylalanine and a phenylalanyl-adenylate analogue (1999), J. Mol. Biol., 287, 555-568.
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
6.1.1.20 enzyme complexed with phenylalanine or the phenylalanyl-adenylate analogue phenylalaninyl-adenylate, X-ray diffraction structure determination at 2.7 and 2.5 A resolution, respectively, and analysis Thermus thermophilus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.1.1.20 ATP + L-phenylalanine + tRNAPhe Thermus thermophilus
-
 AMP + diphosphate + L-phenylalanyl-tRNAPhe
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.1.1.20 Thermus thermophilus
-
 class II enzyme
-

Reaction

EC Number Reaction Comment Organism Reaction ID
6.1.1.20 ATP + L-phenylalanine + tRNAPhe = AMP + diphosphate + L-phenylalanyl-tRNAPhe mechanism, the reaction intermediate is bound to the active site cleft in the catalytic alpha-subunit Thermus thermophilus
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.1.1.20 ATP + L-phenylalanine + tRNAPhe
-
 Thermus thermophilus AMP + diphosphate + L-phenylalanyl-tRNAPhe
-
 ?
6.1.1.20 ATP + L-phenylalanine + tRNAPhe the recognition of Phe through a mixture of van der Waals interactions and hydrogen bonds Thermus thermophilus AMP + diphosphate + L-phenylalanyl-tRNAPhe
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.1.1.20 CML33
-
 Thermus thermophilus
6.1.1.20 FRS
-
 Thermus thermophilus
6.1.1.20 HSPC173
-
 Thermus thermophilus
6.1.1.20 L-Phenylalanyl-tRNA synthetase
-
 Thermus thermophilus
6.1.1.20 Phenylalanine translase
-
 Thermus thermophilus
6.1.1.20 Phenylalanine--tRNA ligase
-
 Thermus thermophilus
6.1.1.20 Phenylalanine-tRNA synthetase
-
 Thermus thermophilus
6.1.1.20 Phenylalanyl transfer ribonucleic acid synthetase
-
 Thermus thermophilus
6.1.1.20 Phenylalanyl-transfer ribonucleate synthetase
-
 Thermus thermophilus
6.1.1.20 Phenylalanyl-transfer RNA ligase
-
 Thermus thermophilus
6.1.1.20 Phenylalanyl-transfer RNA synthetase
-
 Thermus thermophilus
6.1.1.20 Phenylalanyl-tRNA ligase
-
 Thermus thermophilus
6.1.1.20 Phenylalanyl-tRNA synthetase
-
 Thermus thermophilus
6.1.1.20 PheRS
-
 Thermus thermophilus
6.1.1.20 Synthetase, phenylalanyl-transfer ribonucleate
-
 Thermus thermophilus

Cofactor

EC Number Cofactor Comment Organism Structure
6.1.1.20 ATP
-
 Thermus thermophilus