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Literature summary extracted from

  • Hinshaw, J.C.; Suh, D.Y.; Garnier, P.; Buckner, F.S.; Eastman, R.T.; Matsuda, S.P.; Joubert, B.M.; Coppens, I.; Joiner, K.A.; Merali, S.; Nash, T.E.; Prestwich, G.D.
    Oxidosqualene cyclase inhibitors as antimicrobial agents (2003), J. Med. Chem., 46, 4240-4243.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.4.99.7 3-(biphenyl-4-yloxy)-N,N-dimethylpropan-1-amine IC50: 0.016 mM Pneumocystis carinii
5.4.99.7 3-(biphenyl-4-yloxy)-N,N-dimethylpropan-1-amine IC50: 280 nM Trypanosoma brucei
5.4.99.7 3-(biphenyl-4-yloxy)-N,N-dimethylpropan-1-amine IC50: 750 nM Trypanosoma cruzi
5.4.99.7 3-[(4-chlorobenzoyl)-4-phenoxy]quinuclidine IC50: 160 nM Rattus norvegicus
5.4.99.7 additional information oxidosqualene cyclase inhibitors as antimicrobial agents Pneumocystis carinii
5.4.99.7 additional information oxidosqualene cyclase inhibitors as antimicrobial agents Rattus norvegicus
5.4.99.7 additional information oxidosqualene cyclase inhibitors as antimicrobial agents Trypanosoma brucei
5.4.99.7 additional information oxidosqualene cyclase inhibitors as antimicrobial agents Trypanosoma cruzi
5.4.99.7 N-[3-(1,1'-biphenyl-4-yloxy)propyl]-N,N-dimethylamine IC50: 2500 nM Rattus norvegicus
5.4.99.7 [4-(1-azabicyclo[2.2.2]oct-3-yloxy)phenyl](4-chlorophenyl)methanone IC50: 92 nM Pneumocystis carinii
5.4.99.7 [4-(1-azabicyclo[2.2.2]oct-3-yloxy)phenyl](4-chlorophenyl)methanone IC50: 22 nM Trypanosoma brucei
5.4.99.7 [4-(1-azabicyclo[2.2.2]oct-3-yloxy)phenyl](4-chlorophenyl)methanone IC50: 400 nM Trypanosoma cruzi
5.4.99.7 [5-(4-(4-chloro-benzoyl)-3-fluoro-phenoxy)-pentyl]-methyl-propyl-ammonium fumarate IC50: 49 nM Rattus norvegicus
5.4.99.7 {4-[6-(allyl-methyl-amino)-hexyloxy]-2-fluoro-phenyl}-(4-chloro-phenyl)-methanone IC50: 4.6 nM Pneumocystis carinii
5.4.99.7 {4-[6-(allyl-methyl-amino)-hexyloxy]-2-fluoro-phenyl}-(4-chloro-phenyl)-methanone IC50: 4.3 nM Trypanosoma brucei
5.4.99.7 {4-[6-(allyl-methyl-amino)-hexyloxy]-2-fluoro-phenyl}-(4-chloro-phenyl)-methanone IC50: 71 nM Trypanosoma cruzi

Organism

EC Number Organism UniProt Comment Textmining
5.4.99.7 Pneumocystis carinii
-
-
-
5.4.99.7 Rattus norvegicus
-
-
-
5.4.99.7 Trypanosoma brucei
-
-
-
5.4.99.7 Trypanosoma cruzi
-
-
-

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
5.4.99.7 0.0000043
-
 IC50: 4.3 nM Trypanosoma brucei {4-[6-(allyl-methyl-amino)-hexyloxy]-2-fluoro-phenyl}-(4-chloro-phenyl)-methanone
5.4.99.7 0.0000046
-
 IC50: 4.6 nM Pneumocystis carinii {4-[6-(allyl-methyl-amino)-hexyloxy]-2-fluoro-phenyl}-(4-chloro-phenyl)-methanone
5.4.99.7 0.000022
-
 IC50: 22 nM Trypanosoma brucei [4-(1-azabicyclo[2.2.2]oct-3-yloxy)phenyl](4-chlorophenyl)methanone
5.4.99.7 0.000049
-
 IC50: 49 nM Rattus norvegicus [5-(4-(4-chloro-benzoyl)-3-fluoro-phenoxy)-pentyl]-methyl-propyl-ammonium fumarate
5.4.99.7 0.000071
-
 IC50: 71 nM Trypanosoma cruzi {4-[6-(allyl-methyl-amino)-hexyloxy]-2-fluoro-phenyl}-(4-chloro-phenyl)-methanone
5.4.99.7 0.000092
-
 IC50: 92 nM Pneumocystis carinii [4-(1-azabicyclo[2.2.2]oct-3-yloxy)phenyl](4-chlorophenyl)methanone
5.4.99.7 0.00016
-
 IC50: 160 nM Rattus norvegicus 3-[(4-chlorobenzoyl)-4-phenoxy]quinuclidine
5.4.99.7 0.00028
-
 IC50: 280 nM Trypanosoma brucei 3-(biphenyl-4-yloxy)-N,N-dimethylpropan-1-amine
5.4.99.7 0.0004
-
 IC50: 400 nM Trypanosoma cruzi [4-(1-azabicyclo[2.2.2]oct-3-yloxy)phenyl](4-chlorophenyl)methanone
5.4.99.7 0.00075
-
 IC50: 750 nM Trypanosoma cruzi 3-(biphenyl-4-yloxy)-N,N-dimethylpropan-1-amine
5.4.99.7 0.0025
-
 IC50: 2500 nM Rattus norvegicus N-[3-(1,1'-biphenyl-4-yloxy)propyl]-N,N-dimethylamine
5.4.99.7 0.016
-
 IC50: 0.016 mM Pneumocystis carinii 3-(biphenyl-4-yloxy)-N,N-dimethylpropan-1-amine