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Literature summary extracted from

  • Soyka, R.; Guth, B.D.; Weisenberger, H.M.; Luger, P.; Muller, T.H.
    Guanidine derivatives as combined thromboxane A2 receptor antagonists and synthase inhibitors (1999), J. Med. Chem., 42, 1235-1249.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.3.99.5 (5E)-6-(3-(2-cyano-3,3-dimethyl)guanidinophenyl)-6-(3-pyridyl)hex-5-enoic acid 0.000026 mM, 50% inhibition Homo sapiens
5.3.99.5 (5E)-6-(3-(2-cyano-3-(1-adamantyl)-guanidino)phenyl)-6-(3-pyridyl)hex-5-enoic acid 0.000003 mM, 50% inhibition Homo sapiens
5.3.99.5 (5E)-6-(3-(2-cyano-3-(2-dimethylaminoethyl)-guanidino)phenyl)-6-(3-pyridyl)hex-5-enoic acid 0.0029 mM, 50% inhibition Homo sapiens
5.3.99.5 (5E)-6-(3-(2-cyano-3-(2-methylpropyl)guanidino)phenyl)-6-(3-pyridyl)hex-5-enoic acid 0.000025 mM, 50% inhibition Homo sapiens
5.3.99.5 (5E)-6-(3-(2-cyano-3-(3-methylbutyl)guanidino)phenyl)-6-(3-pyridyl)hex-5-enoic acid 0.000003 mM, 50% inhibition Homo sapiens
5.3.99.5 (5E)-6-(3-(2-cyano-3-(3-pyridylmethyl)-guanidino)phenyl)-6-(3-pyridyl)hex-5-enoic acid 0.000032 mM, 50% inhibition Homo sapiens
5.3.99.5 (5E)-6-(3-(2-cyano-3-benzylguanidino)phenyl)-6-(3-pyridyl)hex-5-enoic acid 0.000011 mM, 50% inhibition Homo sapiens
5.3.99.5 (5E)-6-(3-(2-cyano-3-cyclohexyl-guanidino)phenyl)-6-(3-pyridyl)hex-5-enoic acid 0.000003 mM, 50% inhibition Homo sapiens
5.3.99.5 (5E)-6-(3-(2-cyano-3-cyclopentyl-guanidino)phenyl)-6-(3-pyridyl)hex-5-enoic acid 0.000003 mM, 50% inhibition Homo sapiens
5.3.99.5 (5E)-6-(3-(2-cyano-3-cyclopropyl-guanidino)phenyl)-6-(3-pyridyl)hex-5-enoic acid 0.00038 mM, 50% inhibition Homo sapiens
5.3.99.5 (5E)-6-(3-(2-cyano-3-isopropyl)guanidinophenyl)-6-(3-pyridyl)hex-5-enoic acid 0.000024 mM, 50% inhibition Homo sapiens
5.3.99.5 (5E)-6-(3-(2-cyano-3-methyl)guanidinophenyl)-6-(3-pyridyl)hex-5-enoic acid 0.00025 mM, 50% inhibition Homo sapiens
5.3.99.5 (5E)-6-(3-(2-cyano-3-tert-butyl-guanidino)phenyl)-6-(3-pyridyl)hex-5-enoic acid 0.000004 mM, 50% inhibition Homo sapiens
5.3.99.5 (5E)-6-(4-(2-cyano-3-cyclopentyl-guanidino)phenyl)-6-(3-pyridyl)hex-5-enoic acid 0.00018 mM, 50% inhibition Homo sapiens
5.3.99.5 (5E)-6-(4-(2-cyano-3-cyclopropyl-guanidino)phenyl)-6-(3-pyridyl)hex-5-enoic acid 0.0039 mM, 50% inhibition Homo sapiens
5.3.99.5 5E-6-(3-cyanoguanidino)phenyl-6-(3-pyridyl)hex-5-enoic acid 0.00043 mM, 50% inhibition Homo sapiens
5.3.99.5 ridogrel 0.000004 mM, 50% inhibition Homo sapiens
5.3.99.5 samixogrel 0.000004 mM, 50% inhibition Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.3.99.5 (5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate Homo sapiens
-
 (5Z,13E)-(15S)-9alpha,11alpha-epoxy-15-hydroxythromboxa-5,13-dienoate i.e. TXA2 ?

Organism

EC Number Organism UniProt Comment Textmining
5.3.99.5 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.3.99.5 (5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
-
 Homo sapiens (5Z,13E)-(15S)-9alpha,11alpha-epoxy-15-hydroxythromboxa-5,13-dienoate i.e. TXA2 ?

Synonyms

EC Number Synonyms Comment Organism
5.3.99.5 TxSI
-
 Homo sapiens