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Literature summary extracted from

  • Smyth, M.J.; O'Connor, M.D.; Trapani, J.A.; Kershaw, M.H.; Brinkworth, R.I.
    A novel substrate-binding pocket interaction restricts the specificity of the human NK cell-specific serine protease, Met-ase-1 (1996), J. Immunol., 156, 4174-4181.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.21.B2
-
 Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
3.4.21.B2 K179M reduced activity for substrate containing methionine at P1, acquired chymase activity for phenylalanine at P1 Homo sapiens
3.4.21.B2 S201G reduced activity for substrate containing methionine at P1, acquired chymase activity for phenylalanine at P1 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.B2 additional information Homo sapiens participates in target cell death inflicted by cytotoxic lymphocytes ?
-
 ?
3.4.21.B2 Protein + H2O Homo sapiens
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.B2 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.B2 additional information cleaves the carboxyl side of long narrow hydrophobic amino acids, such as methionine, but not large, bulky hydrophobic amino acids such as phenylalanine Homo sapiens ?
-
 ?
3.4.21.B2 additional information participates in target cell death inflicted by cytotoxic lymphocytes Homo sapiens ?
-
 ?
3.4.21.B2 N-tert-butoxycarbonyl-Ala-Ala-Met-thiobenzyl ester + H2O cleaves thiobenzylester substrates specifically after methionine, norleucine or leucine residues in the primary substrate site P1 Homo sapiens N-tert-butoxycarbonyl-Ala-Ala-Met + phenylmethanethiol
-
 ?
3.4.21.B2 Protein + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.B2 Met-ase-1
-
 Homo sapiens
3.4.21.B2 S01.139 Merops ID Homo sapiens