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Literature summary extracted from

  • Jaffe, E.K.
    Investigations on the metal switch region of human porphobilinogen synthase (2003), J. Biol. Inorg. Chem., 8, 176-184.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
4.2.1.24 additional information chimeric proteins that contain the aspartate-rich sequences of the pea enzyme or the enzyme from Pseudomonas aeruginosa in place of the naturally occuring cysteine-rich sequence of the human enzyme. The chimeric enzymes are substantially activated by both magnesium and potassium, but not by zinc. The specific activities of the chimeras are significantly lower than the specific activity of the wild-type enzyme Homo sapiens
4.2.1.24 R221K mutation in wild-type or chimeric enzymes reduces activity Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
4.2.1.24 Mg2+ chimeric proteins are constructed that contain the aspartate-rich sequences of the pea enzyme or the enzyme from Pseudomonas aeruginosa in place of the naturally occuring cysteine-rich sequence of the human enzyme. The chimeric enzymes are substantially activated by both magnesium and potassium, but not by zinc Homo sapiens
4.2.1.24 Zn2+ the cysteines of the metal switch sequence of the wild-type enzyme bind a catalytic zinc. Chimeric proteins are constructed that contain the aspartate-rich sequences of the pea enzyme or the enzyme from Pseudomonas aeruginosa in place of the naturally occuring cysteine-rich sequence of the human enzyme. The chimeric enzymes are substantially activated by both magnesium and potassium, but not by zinc. Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.2.1.24 5-aminolevulinate + 5-aminolevulinate Homo sapiens the enzyme functions in the first common step in tetrapyrrole biosynthesis porphobilinogen + 2 H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.2.1.24 Homo sapiens P13716
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.1.24 5-aminolevulinate + 5-aminolevulinate the enzyme functions in the first common step in tetrapyrrole biosynthesis Homo sapiens porphobilinogen + 2 H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.2.1.24 PBGS
-
 Homo sapiens