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Literature summary extracted from

  • Fukunaga, R.; Fukai, S.; Ishitani, R.; Nureki, O.; Yokoyama, S.
    Crystal structures of the CP1 domain from Thermus thermophilus isoleucyl-tRNA synthetase and its complex with L-valine (2004), J. Biol. Chem., 279, 8396-8402.
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
6.1.1.5 crystallization of CP1 domain alone or in complex with L-valine, X-ray structure determination at 1.8 and 2.0 A resolution respectively, and analysis Thermus thermophilus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.1.1.5 ATP + L-isoleucine + tRNAIle Thermus thermophilus
-
 AMP + diphosphate + L-isoleucyl-tRNAIle
-
 r

Organism

EC Number Organism UniProt Comment Textmining
6.1.1.5 Thermus thermophilus P56690
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
6.1.1.5 ATP + L-isoleucine + tRNAIle = AMP + diphosphate + L-isoleucyl-tRNAIle editing and substrate recognition and binding mechanism, important involved residues are Asp238, Thr228, Thr229, and Thr230 Thermus thermophilus
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.1.1.5 ATP + L-isoleucine + tRNAIle
-
 Thermus thermophilus AMP + diphosphate + L-isoleucyl-tRNAIle
-
 r
6.1.1.5 ATP + L-valine + tRNAIle
-
 Thermus thermophilus AMP + diphosphate + L-valyl-tRNAIle CP1 domain of the enzyme deacylates or edits the mischarged Val-tRNAIle r

Synonyms

EC Number Synonyms Comment Organism
6.1.1.5 IleRS
-
 Thermus thermophilus
6.1.1.5 IRS
-
 Thermus thermophilus
6.1.1.5 Isoleucine translase
-
 Thermus thermophilus
6.1.1.5 Isoleucine--tRNA ligase
-
 Thermus thermophilus
6.1.1.5 Isoleucine-transfer RNA ligase
-
 Thermus thermophilus
6.1.1.5 Isoleucine-tRNA synthetase
-
 Thermus thermophilus
6.1.1.5 Isoleucyl-transfer ribonucleate synthetase
-
 Thermus thermophilus
6.1.1.5 Isoleucyl-transfer RNA synthetase
-
 Thermus thermophilus
6.1.1.5 Isoleucyl-tRNA synthetase
-
 Thermus thermophilus
6.1.1.5 Mupirocin resistance protein
-
 Thermus thermophilus
6.1.1.5 Synthetase, isoleucyl-transfer ribonucleate
-
 Thermus thermophilus

Cofactor

EC Number Cofactor Comment Organism Structure
6.1.1.5 ATP
-
 Thermus thermophilus