Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Lehtonen, J.; Shen, B.; Vihinen, M.; Casini, A.; Scozzafava, A.; Supuran, C.T.; Parkkila, A.K.; Saarnio, J.; Kivelae, A.J.; Waheed, A.; Sly, W.S.; Parkkila, S.
    Characterization of CA XIII, a novel member of the carbonic anhydrase isozyme family (2004), J. Biol. Chem., 279, 2719-2727.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.2.1.1 CA13 gene cDNA Homo sapiens
4.2.1.1 CA13 gene cDNA cloned into Escherichia coli TOP 10 Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.2.1.1 acetazolamide
-
 Homo sapiens
4.2.1.1 acetazolamide
-
 Mus musculus
4.2.1.1 Cyanate
-
 Homo sapiens
4.2.1.1 Cyanate
-
 Mus musculus
4.2.1.1 sulfonamide
-
 Mus musculus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
4.2.1.1 Zn2+
-
 Homo sapiens
4.2.1.1 Zn2+
-
 Mus musculus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
4.2.1.1 30000
-
 Western blotting Homo sapiens
4.2.1.1 30000
-
 Western blotting Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.2.1.1 H2CO3 Homo sapiens
-
 CO2 + H2O
-
 r
4.2.1.1 H2CO3 Mus musculus
-
 CO2 + H2O
-
 r

Organism

EC Number Organism UniProt Comment Textmining
4.2.1.1 Homo sapiens
-
-
-
4.2.1.1 Mus musculus Q9D6N1
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.2.1.1 recombinant His-tagged enzyme Mus musculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.2.1.1 brain
-
 Mus musculus
-
4.2.1.1 colon
-
 Homo sapiens
-
4.2.1.1 embryo
-
 Mus musculus
-
4.2.1.1 enterocyte
-
 Homo sapiens
-
4.2.1.1 heart
-
 Mus musculus
-
4.2.1.1 kidney
-
 Mus musculus
-
4.2.1.1 leukocyte
-
 Homo sapiens
-
4.2.1.1 lung
-
 Mus musculus
-
4.2.1.1 additional information no CA XIII transcript detected in liver Mus musculus
-
4.2.1.1 ovary
-
 Homo sapiens
-
4.2.1.1 prostate
-
 Homo sapiens
-
4.2.1.1 skeletal muscle
-
 Mus musculus
-
4.2.1.1 small intestine
-
 Homo sapiens
-
4.2.1.1 spleen
-
 Homo sapiens
-
4.2.1.1 spleen
-
 Mus musculus
-
4.2.1.1 testis
-
 Homo sapiens
-
4.2.1.1 testis
-
 Mus musculus
-
4.2.1.1 thymus
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.1.1 H2CO3
-
 Homo sapiens CO2 + H2O
-
 r
4.2.1.1 H2CO3
-
 Mus musculus CO2 + H2O
-
 r

Synonyms

EC Number Synonyms Comment Organism
4.2.1.1 CA
-
 Homo sapiens
4.2.1.1 CA
-
 Mus musculus
4.2.1.1 CA XIII
-
 Homo sapiens
4.2.1.1 CA XIII
-
 Mus musculus
4.2.1.1 carbonic anhydrase
-
 Homo sapiens
4.2.1.1 carbonic anhydrase
-
 Mus musculus
4.2.1.1 hCA I
-
 Homo sapiens
4.2.1.1 HCA II
-
 Homo sapiens
4.2.1.1 hCA III
-
 Homo sapiens
4.2.1.1 hCA IV
-
 Homo sapiens
4.2.1.1 hCA IX
-
 Homo sapiens
4.2.1.1 mCA V
-
 Mus musculus
4.2.1.1 mCA XIII
-
 Mus musculus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
4.2.1.1 0.000012
-
 acetazolamide pH 7.5, 25°C, hCA II Homo sapiens
4.2.1.1 0.000017
-
 acetazolamide pH 7.5, 25°C, mCA XIII Mus musculus
4.2.1.1 0.000025
-
 acetazolamide pH 7.5, 25°C, hCA IX Homo sapiens
4.2.1.1 0.00004
-
 acetazolamide pH 7.5, 25°C, hCA IV Homo sapiens
4.2.1.1 0.00006
-
 acetazolamide pH 7.5, 25°C, mCA V Mus musculus
4.2.1.1 0.0002
-
 acetazolamide pH 7.5, 25°C, hCA I Homo sapiens
4.2.1.1 0.00025
-
 Cyanate pH 7.5, 25°C, mCA XIII Mus musculus
4.2.1.1 0.0007
-
 Cyanate pH 7.5, 25°C, hCA I Homo sapiens
4.2.1.1 0.03
-
 Cyanate pH 7.5, 25°C, hCA II and hCA IV Homo sapiens
4.2.1.1 0.031
-
 Cyanate pH 7.5, 25°C, mCA V Mus musculus
4.2.1.1 0.043
-
 Cyanate pH 7.5, 25°C, hCA IX Homo sapiens
4.2.1.1 0.3
-
 acetazolamide pH 7.5, 25°C, hCA III Homo sapiens