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Literature summary extracted from

  • McIninch, J.K.; McIninch, J.D.; May, S.W.
    Catalysis, stereochemistry, and inhibition of ureidoglycolate lyase (2003), J. Biol. Chem., 278, 50091-50100.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.3.2.3 Acetopyruvate
-
 Burkholderia cepacia
4.3.2.3 benzoylpyruvate
-
 Burkholderia cepacia
4.3.2.3 maleamic acid
-
 Burkholderia cepacia
4.3.2.3 N-acetylphenylpyruvate
-
 Burkholderia cepacia

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.3.2.3 0.024
-
 phenylacetyl-alpha-hydroxyglycine 30°C, pH 7.0 Burkholderia cepacia
4.3.2.3 0.025
-
 cinnamoyl-alpha-hydroxyglycine 30°C, pH 7.0 Burkholderia cepacia
4.3.2.3 0.028
-
 4-methoxyphenylacetyl-alpha-hydroxyglycine 30°C, pH 7.0 Burkholderia cepacia
4.3.2.3 0.03
-
 1-naphtylacetyl-alpha-hydroxyglycine 30°C, pH 7.0 Burkholderia cepacia
4.3.2.3 0.04
-
 3-phenylpropionyl-alpha-hydroxyglycine 30°C, pH 7.0 Burkholderia cepacia
4.3.2.3 0.09
-
 benzoyl-alpha-hydroxyglycine 30°C, pH 7.0 Burkholderia cepacia
4.3.2.3 0.09
-
 4'-nitrophenylacetyl-alpha-hydroxyglycine 30°C, pH 7.0 Burkholderia cepacia
4.3.2.3 0.5
-
 (S)-ureidoglycolate 30°C, pH 7.0 Burkholderia cepacia

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.3.2.3 (S)-ureidoglycolate Burkholderia cepacia
-
 glyoxylate + urea
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.3.2.3 Burkholderia cepacia
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.3.2.3 DEAE-Sephacel, oxamate affinity, Superose Burkholderia cepacia

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
4.3.2.3 3.92
-
-
 Burkholderia cepacia

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.3.2.3 (S)-benzoyl-alpha-hydroxyglycine 2% of activity with (S)-ureidoglycolate Burkholderia cepacia glyoxylate + benzamide
-
 ?
4.3.2.3 (S)-cinnamoyl-alpha-hydroxyglycine 5.5% of activity with (S)-ureidoglycolate Burkholderia cepacia glyoxylate + cinnamamide
-
 ?
4.3.2.3 (S)-ureidoglycolate
-
 Burkholderia cepacia glyoxylate + urea
-
 ?
4.3.2.3 1-naphtylacetyl-alpha-hydroxyglycine 2.3% of activity with (S)-ureidoglycolate Burkholderia cepacia glyoxylate + 1-naphtaleneacetamide
-
 ?
4.3.2.3 3-phenylpropionyl-alpha-hydroxyglycine 1.0% of activity with (S)-ureidoglycolate Burkholderia cepacia glyoxylate + 3-phenylpropylacetamide
-
 ?
4.3.2.3 4'-methoxyphenylacetyl-alpha-hydroxyglycine 1.3% of activity with (S)-ureidoglycolate Burkholderia cepacia glyoxylate + 4'-methoxyphenylacetamide
-
 ?
4.3.2.3 4'-nitrophenylacetyl-alpha-hydroxyglycine 0.5% of activity with (S)-ureidoglycolate Burkholderia cepacia glyoxylate + 4'-nitrophenylacetamide
-
 ?
4.3.2.3 benzoyl-alpha-hydroxyglycine
-
 Burkholderia cepacia glyoxylate + benzamide
-
 ?
4.3.2.3 cinnamoyl-alpha-hydroxyglycine
-
 Burkholderia cepacia glyoxylate + cinnamamide
-
 ?
4.3.2.3 phenylacetyl-alpha-hydroxyglycine 0.8% of activity with (S)-ureidoglycolate Burkholderia cepacia glyoxylate + phenylacetamide
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.3.2.3 UGL
-
 Burkholderia cepacia

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
4.3.2.3 0.0000022
-
 benzoylpyruvate 30°C, pH 7.0 Burkholderia cepacia
4.3.2.3 0.00056
-
 Acetopyruvate 30°C, pH 7.0 Burkholderia cepacia
4.3.2.3 0.0012
-
 N-acetylphenylpyruvate 30°C, pH 7.0 Burkholderia cepacia
4.3.2.3 11.6
-
 maleamic acid 30°C, pH 7.0 Burkholderia cepacia