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Literature summary extracted from

  • Majerus, E.M.; Zheng, X.; Tuley, E.A.; Sadler, J.E.
    Cleavage of the ADAMTS13 propeptide is not required for protease activity (2003), J. Biol. Chem., 278, 46643-46648.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.24.87 Urea activates at 1 M Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.24.87 transient expression in HeLa cells, in HepG2 cells, in RFL6 cells, and in COS-1 cells, highest expression level is obtained in HeLa cells Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.24.87 extracellular plasma Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.87 proteins + H2O Homo sapiens
-
 peptides
-
 ?
3.4.24.87 von Willebrand factor + H2O Homo sapiens large multimeric substrate, cleavage of the peptide bond Tyr842-Met843 within the A2 domain 2 peptides of 140 kDa and 176 kDa
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.87 Homo sapiens
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.24.87 glycoprotein enzym contains 10 potential N-glycosylation sites Homo sapiens
3.4.24.87 proteolytic modification propeptide is very short and poorly conserved, dispensable for protein folding, is cleaved off by furin after export from the endoplasmic reticulum, the pro-enzyme form is fully active Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.87 plasma
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.87 additional information pro-von Willebrand factor is cleaved by pro-ADAMTS13 and by ADAMTS13 Homo sapiens ?
-
 ?
3.4.24.87 proteins + H2O
-
 Homo sapiens peptides
-
 ?
3.4.24.87 von Willebrand factor + H2O cleavage of the peptide bond Tyr842-Met843 within the A2 domain Homo sapiens 2 peptides of 140 kDa and 176 kDa
-
 ?
3.4.24.87 von Willebrand factor + H2O large multimeric substrate, cleavage of the peptide bond Tyr842-Met843 within the A2 domain Homo sapiens 2 peptides of 140 kDa and 176 kDa
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.87 ADAMTS13 i.e. a disintegrin and metalloprotease with thrombospondin repeats Homo sapiens
3.4.24.87 M12.241 Merops-ID Homo sapiens
3.4.24.87 von-Willebrand factor cleaving protease
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.24.87 22
-
 room temperature, assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.24.87 8
-
 assay at Homo sapiens