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Literature summary extracted from

  • Pietsch, M.; Gutschow, M.
    Alternate substrate inhibition of cholesterol esterase by thieno[2,3-d][1,3]oxazin-4-ones (2002), J. Biol. Chem., 277, 24006-24013.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.13 2-(diethylamino)-4H-3,1-benzoxazin-4-one substrate inhibitor Bos taurus
3.1.1.13 2-(diethylamino)-4H-thieno[2,3-d][1,3]oxazin-4-one substrate inhibitor Bos taurus
3.1.1.13 2-(diethylamino)-4H-thieno[2,3-d][1,3]thiazin-4-one substrate inhibitor Bos taurus
3.1.1.13 2-(diethylamino)-5,6,7,8-tetrahydro-4H-[1]benzothieno[2,3-d][1,3]oxazin-4-one substrate inhibitor Bos taurus
3.1.1.13 2-(diethylamino)-6,7-dihydro-4H,5H-cyclopenta[4,5]thieno[2,3-d][1,3]oxazin-4-one substrate inhibitor Bos taurus
3.1.1.13 2-(diethylamino)-6,7-dihydro-4H,5H-cyclopenta[4,5]thieno[2,3-d][1,3]thiazin-4-one substrate inhibitor Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.13 Bos taurus
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
3.1.1.13 steryl ester + H2O = sterol + fatty acid a group of enzymes of broad specificity, acting on esters of sterols and long-chain fatty acids, that may also bring about the esterification of sterols. Activated by bile salts Bos taurus
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.13 pancreas
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.13 2-(diethylamino)-4H-3,1-benzoxazin-4-one + H2O
-
 Bos taurus ?
-
 ?
3.1.1.13 2-(diethylamino)-4H-thieno[2,3-d][1,3]oxazin-4-one + H2O
-
 Bos taurus ?
-
 ?
3.1.1.13 2-(diethylamino)-4H-thieno[2,3-d][1,3]thiazin-4-one + H2O
-
 Bos taurus ?
-
 ?
3.1.1.13 2-(diethylamino)-5,6,7,8-tetrahydro-4H-[1]benzothieno[2,3-d][1,3]oxazin-4-one + H2O
-
 Bos taurus ?
-
 ?
3.1.1.13 2-(diethylamino)-6,7-dihydro-4H,5H-cyclopenta[4,5]thieno[2,3-d][1,3]oxazin-4-one + H2O
-
 Bos taurus ?
-
 ?
3.1.1.13 2-(diethylamino)-6,7-dihydro-4H,5H-cyclopenta[4,5]thieno[2,3-d][1,3]thiazin-4-one + H2O
-
 Bos taurus ?
-
 ?
3.1.1.13 4-nitrophenyl butyrate + H2O
-
 Bos taurus 4-nitrophenol + butyrate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.13 CEase
-
 Bos taurus
3.1.1.13 cholesterol esterase
-
 Bos taurus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.1.13 25
-
 assay at Bos taurus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.1.13 7
-
 assay at Bos taurus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.1.1.13 additional information
-
 additional information inhibition kinetics Bos taurus
3.1.1.13 0.00058
-
 2-(diethylamino)-6,7-dihydro-4H,5H-cyclopenta[4,5]thieno[2,3-d][1,3]oxazin-4-one pH 7.0, 25°C Bos taurus
3.1.1.13 0.0019
-
 2-(diethylamino)-5,6,7,8-tetrahydro-4H-[1]benzothieno[2,3-d][1,3]oxazin-4-one pH 7.0, 25°C Bos taurus
3.1.1.13 0.053
-
 2-(diethylamino)-4H-3,1-benzoxazin-4-one pH 7.0, 25°C Bos taurus