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Literature summary extracted from

  • Lawrence, A.J.; Coote, J.G.; Kazi, Y.F.; Lawrence, P.D.; MacDonald-Fyall, J.; Orr, B.M.; Parton, R.; Riehle, M.; Sinclair, J.; Young, J.; Price, N.C.
    A direct pyrophosphatase-coupled assay provides new insights into the activation of the secreted adenylate cyclase from Bordetella pertussis by calmodulin (2002), J. Biol. Chem., 277, 22289-22296.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
4.6.1.1 Calmodulin strong activation Bordetella pertussis

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.6.1.1 expression in Escherichia coli Bordetella pertussis

General Stability

EC Number General Stability Organism
4.6.1.1 calmodulin stablizes CyaA Bordetella pertussis

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.6.1.1 EGTA freshly activated CyaA is inhibited by EGTA at low calmodulin concentrations Bordetella pertussis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.6.1.1 ATP Bordetella pertussis
-
3',5'-cyclic AMP + diphosphate
-
?

Organism

EC Number Organism UniProt Comment Textmining
4.6.1.1 Bordetella pertussis
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.6.1.1 recombinant CyaA Bordetella pertussis

Storage Stability

EC Number Storage Stability Organism
4.6.1.1 -20°C, 8 M urea, no loss of activity Bordetella pertussis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.6.1.1 ATP
-
Bordetella pertussis 3',5'-cyclic AMP + diphosphate
-
?

Synonyms

EC Number Synonyms Comment Organism
4.6.1.1 adenylate cyclase toxin
-
Bordetella pertussis
4.6.1.1 CyaA
-
Bordetella pertussis