Literature summary extracted from
Jaffe, E.K.; Kervinen, J.; Martins, J.; Stauffer, F.; Neier, R.; Wlodawer, A.; Zdanov, A.
Species-specific inhibition of porphobilinogen synthase by 4-oxosebacic acid (2002), J. Biol. Chem., 277, 19792-19799.
Crystallization (Commentary)
EC Number |
Crystallization (Comment) |
Organism |
---|
4.2.1.24 |
crystal structure of enzyme complexed with 4-oxosebaic acid and of enzyme complexed with 4,7-dioxosebaic acid |
Escherichia coli |
Inhibitors
EC Number |
Inhibitors |
Comment |
Organism |
Structure |
---|
4.2.1.24 |
4,7-dioxosebaic acid |
- |
Escherichia coli |
|
4.2.1.24 |
4-oxosebaic acid |
active site-directed irreversible inhibitor, less potent than 4,7-dioxosebaic acid |
Escherichia coli |
|
Metals/Ions
EC Number |
Metals/Ions |
Comment |
Organism |
Structure |
---|
4.2.1.24 |
Zn2+ |
enzyme uses a catalytic Zn2+ |
Escherichia coli |
|
Natural Substrates/ Products (Substrates)
EC Number |
Natural Substrates |
Organism |
Comment (Nat. Sub.) |
Natural Products |
Comment (Nat. Pro.) |
Rev. |
Reac. |
---|
4.2.1.24 |
5-aminolevulinate + 5-aminolevulinate |
Escherichia coli |
essential step in tetrapyrrole biosynthesis |
porphobilinogen + 2 H2O |
- |
? |
|
Organism
EC Number |
Organism |
UniProt |
Comment |
Textmining |
---|
4.2.1.24 |
Escherichia coli |
P0ACB2 |
- |
- |
Substrates and Products (Substrate)
EC Number |
Substrates |
Comment Substrates |
Organism |
Products |
Comment (Products) |
Rev. |
Reac. |
---|
4.2.1.24 |
5-aminolevulinate + 5-aminolevulinate |
essential step in tetrapyrrole biosynthesis |
Escherichia coli |
porphobilinogen + 2 H2O |
- |
? |
|