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Literature summary extracted from

  • Vlasie, M.; Chowdhury, S.; Banerjee, R.
    Importance of the histidine ligand to coenzyme B12 in the reaction catalyzed by methylmalonyl-CoA mutase (2002), J. Biol. Chem., 277, 18523-18527.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
5.4.99.2
-
Propionibacterium freudenreichii subsp. shermanii

Protein Variants

EC Number Protein Variants Comment Organism
5.4.99.2 H610A weakened affinity to the cofactor and much lower turnover than wild-type enzyme Propionibacterium freudenreichii subsp. shermanii
5.4.99.2 H610N weakened affinity to the cofactor and much lower turnover than wild-type enzyme Propionibacterium freudenreichii subsp. shermanii

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
5.4.99.2 0.00024
-
adenosylcobalamin 37°C, wild-type Propionibacterium freudenreichii subsp. shermanii
5.4.99.2 0.00045
-
adenosylcobalamin 37°C, mutant H610A Propionibacterium freudenreichii subsp. shermanii
5.4.99.2 0.00052
-
adenosylcobalamin 37°C, mutant H610N Propionibacterium freudenreichii subsp. shermanii
5.4.99.2 0.102
-
(R)-2-methylmalonyl-CoA 37°C, mutant H610N Propionibacterium freudenreichii subsp. shermanii
5.4.99.2 0.133
-
(R)-2-methylmalonyl-CoA 37°C, wild-type Propionibacterium freudenreichii subsp. shermanii
5.4.99.2 0.364
-
(R)-2-methylmalonyl-CoA 37°C, mutant H610A Propionibacterium freudenreichii subsp. shermanii

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.4.99.2 (R)-2-methylmalonyl-CoA Propionibacterium freudenreichii subsp. shermanii
-
succinyl-CoA
-
?

Organism

EC Number Organism UniProt Comment Textmining
5.4.99.2 Propionibacterium freudenreichii subsp. shermanii
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
5.4.99.2
-
Propionibacterium freudenreichii subsp. shermanii

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.4.99.2 (R)-2-methylmalonyl-CoA
-
Propionibacterium freudenreichii subsp. shermanii succinyl-CoA
-
?

Synonyms

EC Number Synonyms Comment Organism
5.4.99.2 methylmalonyl-CoA mutase
-
Propionibacterium freudenreichii subsp. shermanii

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
5.4.99.2 0.003
-
(R)-2-methylmalonyl-CoA 37°C, mutant H610N Propionibacterium freudenreichii subsp. shermanii
5.4.99.2 0.024
-
(R)-2-methylmalonyl-CoA 37°C, mutant H610A Propionibacterium freudenreichii subsp. shermanii
5.4.99.2 120
-
(R)-2-methylmalonyl-CoA 37°C, wild-type Propionibacterium freudenreichii subsp. shermanii

Cofactor

EC Number Cofactor Comment Organism Structure
5.4.99.2 adenosylcobalamin
-
Propionibacterium freudenreichii subsp. shermanii