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Literature summary extracted from

  • Wrenger, C.; Luersen, K.; Krause, T.; Muller, S.; Walter, R.D.
    The Plasmodium falciparum bifunctional ornithine decarboxylase, S-adenosyl-L-methionine decarboxylase, enables a well balanced polyamine synthesis without domain-domain interaction (2001), J. Biol. Chem., 276, 29651-29656.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.1.1.17 expression of Strep-tactin-PfODC/AdoMetDC fusion in Escherichia coli Plasmodium falciparum

Protein Variants

EC Number Protein Variants Comment Organism
4.1.1.17 C1355A 8.7% of wild-type activity Plasmodium falciparum
4.1.1.17 D1356A 8% of wild-type activity Plasmodium falciparum
4.1.1.17 D1359A 3% of wild-type activity Plasmodium falciparum
4.1.1.17 G1382Y no ODC activity Plasmodium falciparum
4.1.1.17 K868A no ODC activity Plasmodium falciparum
4.1.1.17 K970A no ODC activity Plasmodium falciparum
4.1.1.17 S73A no AdometDC, i.e. ec4.1.1.50, activity, 90% of wild-type ODC activity Plasmodium falciparum

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.1.1.17 putrescine
-
Plasmodium falciparum

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.1.1.17 0.041
-
L-ornithine recombinant PfODC Plasmodium falciparum

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.1.1.17 L-ornithine Plasmodium falciparum first step in polyamine biosynthesis putrescine + CO2
-
?

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.17 Plasmodium falciparum
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.1.1.17 recombinant PfODC Plasmodium falciparum

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
4.1.1.17 0.0388
-
recombinant PfODC Plasmodium falciparum

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.17 L-ornithine
-
Plasmodium falciparum putrescine + CO2
-
?
4.1.1.17 L-ornithine first step in polyamine biosynthesis Plasmodium falciparum putrescine + CO2
-
?
4.1.1.17 additional information bifunctional enzyme having both ODC and AdoMetDC, i.e. EC4.1.1.50, activity Plasmodium falciparum ?
-
?

Synonyms

EC Number Synonyms Comment Organism
4.1.1.17 PfODC/AdoMetDC
-
Plasmodium falciparum

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
4.1.1.17 8
-
-
Plasmodium falciparum

pH Range

EC Number pH Minimum pH Maximum Comment Organism
4.1.1.17 7 8.5
-
Plasmodium falciparum

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
4.1.1.17 0.068
-
putrescine
-
Plasmodium falciparum