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Literature summary extracted from
- Molecular characterization of the 4'-phosphopantothenoylcysteine decarboxylase domain of bacterial Dfp flavoproteins (2001), J. Biol. Chem., 276, 27597-27604.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 4.1.1.36 | 5'partof the dfp gene is cloned and overexpressed | Escherichia coli |
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 4.1.1.36 | A17D | site-directed mutagenesis | Escherichia coli |
| 4.1.1.36 | G14S | site-directed mutagenesis | Escherichia coli |
| 4.1.1.36 | G15A | site-directed mutagenesis | Escherichia coli |
| 4.1.1.36 | I16L | site-directed mutagenesis | Escherichia coli |
| 4.1.1.36 | K20N | site-directed mutagenesis | Escherichia coli |
| 4.1.1.36 | K20Q | site-directed mutagenesis | Escherichia coli |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 4.1.1.36 | 20100 | - |
12 * 20100, homododecamer, SDS-PAGE | Escherichia coli |
| 4.1.1.36 | 270000 | - |
CoAC domain, gel filtration | Escherichia coli |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.1.1.36 | N-[(R)-4'-phosphopantothenoyl]-L-cysteine | Escherichia coli | key step in coenzyme A biosynthesis | pantotheine 4'-phosphate + CO2 | - |
? |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 4.1.1.36 | Escherichia coli | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 4.1.1.36 | - |
Escherichia coli |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.1.1.36 | N-[(R)-4'-phosphopantothenoyl]-L-cysteine | - |
Escherichia coli | pantotheine 4'-phosphate + CO2 | - |
? | |
| 4.1.1.36 | N-[(R)-4'-phosphopantothenoyl]-L-cysteine | key step in coenzyme A biosynthesis | Escherichia coli | pantotheine 4'-phosphate + CO2 | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 4.1.1.36 | dodecamer | 12 * 20100, homododecamer, SDS-PAGE | Escherichia coli |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 4.1.1.36 | dfp flavoprotein | - |
Escherichia coli |
| 4.1.1.36 | PPC decarboxylase | - |
Escherichia coli |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.1.1.36 | flavin | flavin-containing Cys decarboxylase | Escherichia coli | |
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