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Literature summary extracted from

  • Nathanson, L.; Deutscher, M.P.
    Active aminoacyl-tRNA synthetases are present in nuclei as a high molecular weight multienzyme complex (2000), J. Biol. Chem., 275, 31559-31562.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
6.1.1.3 cytoplasm major part, enzyme participates in a multienzyme complex, not as large and stable as the one from nucleus Cricetulus griseus 5737
-
6.1.1.3 cytoplasm major part, enzyme participates in a multienzyme complex, not as large and stable as the one from nucleus Oryctolagus cuniculus 5737
-
6.1.1.3 nucleus 0.15% of total activity in the cell, enzyme participates in a large and stable multienzyme complex Oryctolagus cuniculus 5634
-
6.1.1.3 nucleus 0.4% of total activity in the cell, enzyme participates in a large and stable multienzyme complex Cricetulus griseus 5634
-
6.1.1.4 cytoplasm major part, enzyme participates in a multienzyme complex, not as large and stable as the one from nucleus Cricetulus griseus 5737
-
6.1.1.4 nucleus 2.4% of total activity in the cell, enzyme participates in a large and stable multienzyme complex Cricetulus griseus 5634
-
6.1.1.5 cytoplasm major part, enzyme participates in a multienzyme complex, not as large and stable as the one from nucleus Cricetulus griseus 5737
-
6.1.1.5 cytoplasm major part, enzyme participates in a multienzyme complex, not as large and stable as the one from nucleus Oryctolagus cuniculus 5737
-
6.1.1.5 nucleus 0.32% of total activity in the cell, enzyme participates in a large and stable multienzyme complex Oryctolagus cuniculus 5634
-
6.1.1.5 nucleus 1.3% of total activity in the cell, enzyme participates in a large and stable multienzyme complex Cricetulus griseus 5634
-
6.1.1.6 cytoplasm major part, enzyme participates in a multienzyme complex, not as large and stable as the one from nucleus Cricetulus griseus 5737
-
6.1.1.6 cytoplasm major part, enzyme participates in a multienzyme complex, not as large and stable as the one from nucleus Oryctolagus cuniculus 5737
-
6.1.1.6 nucleus 0.67% of total enzyme amount in the cell, enzyme participates in a large and stable multienzyme complex Oryctolagus cuniculus 5634
-
6.1.1.6 nucleus 3.1% of total enzyme amount in the cell, enzyme participates in a large and stable multienzyme complex Cricetulus griseus 5634
-
6.1.1.15 cytoplasm major part, enzyme participates in a multienzyme complex, not as large and stable as the one from nucleus Cricetulus griseus 5737
-
6.1.1.15 nucleus 2.9% of total activity in the cell, enzyme participates in a large and stable multienzyme complex Cricetulus griseus 5634
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.1.1.3 ATP + L-isoleucine + tRNAIle Oryctolagus cuniculus the reaction catalyzed by the enzyme plays an important role in the transport of aminoacylated tRNAs from the nucleus to the cytoplasm AMP + diphosphate + L-isoleucyl-tRNAIle
-
 ?
6.1.1.3 ATP + L-threonine + tRNAThr Cricetulus griseus the reaction catalyzed by the enzyme plays an important role in the transport of aminoacylated tRNAs from the nucleus to the cytoplasm AMP + diphosphate + L-threonyl-tRNAThr
-
 ?
6.1.1.3 additional information Cricetulus griseus aminoacyl-tRNA is channeled in vivo by probably direct transfer to elongation factor I ?
-
 ?
6.1.1.3 additional information Oryctolagus cuniculus aminoacyl-tRNA is channeled in vivo by probably direct transfer to elongation factor I ?
-
 ?
6.1.1.4 ATP + L-leucine + tRNALeu Cricetulus griseus the reaction catalyzed by the enzyme plays an important role in the transport of aminoacylated tRNAs from the nucleus to the cytoplasm AMP + diphosphate + L-leucyl-tRNALeu
-
 ?
6.1.1.4 additional information Cricetulus griseus aminoacyl-tRNA is channeled in vivo by probably direct transfer to elongation factor I ?
-
 ?
6.1.1.5 ATP + L-isoleucine + tRNAIle Oryctolagus cuniculus the reaction catalyzed by the enzyme plays an important role in the transport of aminoacylated tRNAs from the nucleus to the cytoplasm AMP + diphosphate + L-isoleucyl-tRNAIle
-
 ?
6.1.1.5 ATP + L-isoleucine + tRNAIle Cricetulus griseus the reaction plays an important role in the transport of aminoacylated tRNAs from the nucleus to the cytoplasm AMP + diphosphate + L-isoleucyl-tRNAIle
-
 ?
6.1.1.5 additional information Cricetulus griseus aminoacyl-tRNA is channeled in vivo by probably direct transfer to elongation factor I ?
-
 ?
6.1.1.5 additional information Oryctolagus cuniculus aminoacyl-tRNA is channeled in vivo by probably direct transfer to elongation factor I ?
-
 ?
6.1.1.6 ATP + L-lysine + tRNALys Cricetulus griseus the reaction catalyzed by the enzyme plays an important role in the transport of aminoacylated tRNAs from the nucleus to the cytoplasm AMP + diphosphate + L-lysyl-tRNALys
-
 ?
6.1.1.6 ATP + L-lysine + tRNALys Oryctolagus cuniculus the reaction catalyzed by the enzyme plays an important role in the transport of aminoacylated tRNAs from the nucleus to the cytoplasm AMP + diphosphate + L-lysyl-tRNALys
-
 ?
6.1.1.6 additional information Cricetulus griseus aminoacyl-tRNA is channeled in vivo by probably direct transfer to elongation factor I ?
-
 ?
6.1.1.6 additional information Oryctolagus cuniculus aminoacyl-tRNA is channeled in vivo by probably direct transfer to elongation factor I ?
-
 ?
6.1.1.15 ATP + L-proline + tRNAPro Cricetulus griseus the reaction catalyzed by the enzyme plays an important role in the transport of aminoacylated tRNAs from the nucleus to the cytoplasm AMP + diphosphate + L-prolyl-tRNAPro
-
 ?
6.1.1.15 additional information Cricetulus griseus aminoacyl-tRNA is channeled in vivo by probably direct transfer to elongation factor I ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.1.1.3 Cricetulus griseus
-
-
-
6.1.1.3 Oryctolagus cuniculus
-
-
-
6.1.1.4 Cricetulus griseus
-
-
-
6.1.1.5 Cricetulus griseus
-
-
-
6.1.1.5 Oryctolagus cuniculus
-
-
-
6.1.1.6 Cricetulus griseus
-
-
-
6.1.1.6 Oryctolagus cuniculus
-
-
-
6.1.1.14 Cricetulus griseus
-
-
-
6.1.1.14 Oryctolagus cuniculus
-
-
-
6.1.1.15 Cricetulus griseus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.1.1.3 kidney cell line LCC-RK1 Oryctolagus cuniculus
-
6.1.1.3 ovary cell line CRL-1781 Cricetulus griseus
-
6.1.1.4 ovary cell line CRL-1781 Cricetulus griseus
-
6.1.1.5 kidney cell line LCC-RK1 Oryctolagus cuniculus
-
6.1.1.5 ovary cell line CRL-1781 Cricetulus griseus
-
6.1.1.6 kidney cell line LCC-RK1 Oryctolagus cuniculus
-
6.1.1.6 ovary cell line CRL-1781 Cricetulus griseus
-
6.1.1.15 ovary cell line CRL-1781 Cricetulus griseus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
6.1.1.3 additional information
-
-
 Cricetulus griseus
6.1.1.3 additional information
-
-
 Oryctolagus cuniculus
6.1.1.4 additional information
-
-
 Cricetulus griseus
6.1.1.5 additional information
-
-
 Cricetulus griseus
6.1.1.5 additional information
-
-
 Oryctolagus cuniculus
6.1.1.6 additional information
-
-
 Cricetulus griseus
6.1.1.6 additional information
-
-
 Oryctolagus cuniculus
6.1.1.15 additional information
-
-
 Cricetulus griseus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.1.1.3 ATP + L-isoleucine + tRNAIle
-
 Oryctolagus cuniculus AMP + diphosphate + L-isoleucyl-tRNAIle
-
 ?
6.1.1.3 ATP + L-isoleucine + tRNAIle the reaction catalyzed by the enzyme plays an important role in the transport of aminoacylated tRNAs from the nucleus to the cytoplasm Oryctolagus cuniculus AMP + diphosphate + L-isoleucyl-tRNAIle
-
 ?
6.1.1.3 ATP + L-threonine + tRNAThr
-
 Cricetulus griseus AMP + diphosphate + L-threonyl-tRNAThr
-
 ?
6.1.1.3 ATP + L-threonine + tRNAThr the reaction catalyzed by the enzyme plays an important role in the transport of aminoacylated tRNAs from the nucleus to the cytoplasm Cricetulus griseus AMP + diphosphate + L-threonyl-tRNAThr
-
 ?
6.1.1.3 additional information aminoacyl-tRNA is channeled in vivo by probably direct transfer to elongation factor I Cricetulus griseus ?
-
 ?
6.1.1.3 additional information aminoacyl-tRNA is channeled in vivo by probably direct transfer to elongation factor I Oryctolagus cuniculus ?
-
 ?
6.1.1.4 ATP + L-leucine + tRNALeu
-
 Cricetulus griseus AMP + diphosphate + L-leucyl-tRNALeu
-
 ?
6.1.1.4 ATP + L-leucine + tRNALeu the reaction catalyzed by the enzyme plays an important role in the transport of aminoacylated tRNAs from the nucleus to the cytoplasm Cricetulus griseus AMP + diphosphate + L-leucyl-tRNALeu
-
 ?
6.1.1.4 additional information aminoacyl-tRNA is channeled in vivo by probably direct transfer to elongation factor I Cricetulus griseus ?
-
 ?
6.1.1.5 ATP + L-isoleucine + tRNAIle
-
 Cricetulus griseus AMP + diphosphate + L-isoleucyl-tRNAIle
-
 ?
6.1.1.5 ATP + L-isoleucine + tRNAIle
-
 Oryctolagus cuniculus AMP + diphosphate + L-isoleucyl-tRNAIle
-
 ?
6.1.1.5 ATP + L-isoleucine + tRNAIle the reaction catalyzed by the enzyme plays an important role in the transport of aminoacylated tRNAs from the nucleus to the cytoplasm Oryctolagus cuniculus AMP + diphosphate + L-isoleucyl-tRNAIle
-
 ?
6.1.1.5 ATP + L-isoleucine + tRNAIle the reaction plays an important role in the transport of aminoacylated tRNAs from the nucleus to the cytoplasm Cricetulus griseus AMP + diphosphate + L-isoleucyl-tRNAIle
-
 ?
6.1.1.5 additional information aminoacyl-tRNA is channeled in vivo by probably direct transfer to elongation factor I Cricetulus griseus ?
-
 ?
6.1.1.5 additional information aminoacyl-tRNA is channeled in vivo by probably direct transfer to elongation factor I Oryctolagus cuniculus ?
-
 ?
6.1.1.6 ATP + L-lysine + tRNALys
-
 Cricetulus griseus AMP + diphosphate + L-lysyl-tRNALys
-
 ?
6.1.1.6 ATP + L-lysine + tRNALys
-
 Oryctolagus cuniculus AMP + diphosphate + L-lysyl-tRNALys
-
 ?
6.1.1.6 ATP + L-lysine + tRNALys the reaction catalyzed by the enzyme plays an important role in the transport of aminoacylated tRNAs from the nucleus to the cytoplasm Cricetulus griseus AMP + diphosphate + L-lysyl-tRNALys
-
 ?
6.1.1.6 ATP + L-lysine + tRNALys the reaction catalyzed by the enzyme plays an important role in the transport of aminoacylated tRNAs from the nucleus to the cytoplasm Oryctolagus cuniculus AMP + diphosphate + L-lysyl-tRNALys
-
 ?
6.1.1.6 additional information aminoacyl-tRNA is channeled in vivo by probably direct transfer to elongation factor I Cricetulus griseus ?
-
 ?
6.1.1.6 additional information aminoacyl-tRNA is channeled in vivo by probably direct transfer to elongation factor I Oryctolagus cuniculus ?
-
 ?
6.1.1.15 ATP + L-proline + tRNAPro
-
 Cricetulus griseus AMP + diphosphate + L-prolyl-tRNAPro
-
 ?
6.1.1.15 ATP + L-proline + tRNAPro the reaction catalyzed by the enzyme plays an important role in the transport of aminoacylated tRNAs from the nucleus to the cytoplasm Cricetulus griseus AMP + diphosphate + L-prolyl-tRNAPro
-
 ?
6.1.1.15 additional information aminoacyl-tRNA is channeled in vivo by probably direct transfer to elongation factor I Cricetulus griseus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.1.1.3 Synthetase, threonyl-transfer ribonucleate
-
 Cricetulus griseus
6.1.1.3 Synthetase, threonyl-transfer ribonucleate
-
 Oryctolagus cuniculus
6.1.1.3 Threonine translase
-
 Cricetulus griseus
6.1.1.3 Threonine translase
-
 Oryctolagus cuniculus
6.1.1.3 Threonine--tRNA ligase
-
 Cricetulus griseus
6.1.1.3 Threonine--tRNA ligase
-
 Oryctolagus cuniculus
6.1.1.3 Threonine-transfer ribonucleate synthetase
-
 Cricetulus griseus
6.1.1.3 Threonine-transfer ribonucleate synthetase
-
 Oryctolagus cuniculus
6.1.1.3 Threonyl-ribonucleic synthetase
-
 Cricetulus griseus
6.1.1.3 Threonyl-ribonucleic synthetase
-
 Oryctolagus cuniculus
6.1.1.3 Threonyl-transfer ribonucleate synthetase
-
 Cricetulus griseus
6.1.1.3 Threonyl-transfer ribonucleate synthetase
-
 Oryctolagus cuniculus
6.1.1.3 Threonyl-transfer ribonucleic acid synthetase
-
 Cricetulus griseus
6.1.1.3 Threonyl-transfer ribonucleic acid synthetase
-
 Oryctolagus cuniculus
6.1.1.3 Threonyl-transfer RNA synthetase
-
 Cricetulus griseus
6.1.1.3 Threonyl-transfer RNA synthetase
-
 Oryctolagus cuniculus
6.1.1.3 Threonyl-tRNA synthetase
-
 Cricetulus griseus
6.1.1.3 Threonyl-tRNA synthetase
-
 Oryctolagus cuniculus
6.1.1.3 ThrRS
-
 Cricetulus griseus
6.1.1.3 ThrRS
-
 Oryctolagus cuniculus
6.1.1.3 TRS
-
 Cricetulus griseus
6.1.1.3 TRS
-
 Oryctolagus cuniculus
6.1.1.4 Leucine translase
-
 Cricetulus griseus
6.1.1.4 Leucine--tRNA ligase
-
 Cricetulus griseus
6.1.1.4 Leucyl-transfer ribonucleate synthetase
-
 Cricetulus griseus
6.1.1.4 Leucyl-transfer ribonucleic acid synthetase
-
 Cricetulus griseus
6.1.1.4 Leucyl-transfer RNA synthetase
-
 Cricetulus griseus
6.1.1.4 Leucyl-tRNA synthetase
-
 Cricetulus griseus
6.1.1.4 LeuRS
-
 Cricetulus griseus
6.1.1.4 Synthetase, leucyl-transfer ribonucleate
-
 Cricetulus griseus
6.1.1.5 IleRS
-
 Cricetulus griseus
6.1.1.5 IleRS
-
 Oryctolagus cuniculus
6.1.1.5 IRS
-
 Cricetulus griseus
6.1.1.5 IRS
-
 Oryctolagus cuniculus
6.1.1.5 Isoleucine translase
-
 Cricetulus griseus
6.1.1.5 Isoleucine translase
-
 Oryctolagus cuniculus
6.1.1.5 Isoleucine--tRNA ligase
-
 Cricetulus griseus
6.1.1.5 Isoleucine--tRNA ligase
-
 Oryctolagus cuniculus
6.1.1.5 Isoleucine-transfer RNA ligase
-
 Cricetulus griseus
6.1.1.5 Isoleucine-transfer RNA ligase
-
 Oryctolagus cuniculus
6.1.1.5 Isoleucine-tRNA synthetase
-
 Cricetulus griseus
6.1.1.5 Isoleucine-tRNA synthetase
-
 Oryctolagus cuniculus
6.1.1.5 Isoleucyl-transfer ribonucleate synthetase
-
 Cricetulus griseus
6.1.1.5 Isoleucyl-transfer ribonucleate synthetase
-
 Oryctolagus cuniculus
6.1.1.5 Isoleucyl-transfer RNA synthetase
-
 Cricetulus griseus
6.1.1.5 Isoleucyl-transfer RNA synthetase
-
 Oryctolagus cuniculus
6.1.1.5 Isoleucyl-tRNA synthetase
-
 Cricetulus griseus
6.1.1.5 Isoleucyl-tRNA synthetase
-
 Oryctolagus cuniculus
6.1.1.5 Mupirocin resistance protein
-
 Cricetulus griseus
6.1.1.5 Mupirocin resistance protein
-
 Oryctolagus cuniculus
6.1.1.5 Synthetase, isoleucyl-transfer ribonucleate
-
 Cricetulus griseus
6.1.1.5 Synthetase, isoleucyl-transfer ribonucleate
-
 Oryctolagus cuniculus
6.1.1.6 L-Lysine-transfer RNA ligase
-
 Cricetulus griseus
6.1.1.6 L-Lysine-transfer RNA ligase
-
 Oryctolagus cuniculus
6.1.1.6 Lysine translase
-
 Cricetulus griseus
6.1.1.6 Lysine translase
-
 Oryctolagus cuniculus
6.1.1.6 Lysine--tRNA ligase
-
 Cricetulus griseus
6.1.1.6 Lysine--tRNA ligase
-
 Oryctolagus cuniculus
6.1.1.6 Lysine-tRNA synthetase
-
 Cricetulus griseus
6.1.1.6 Lysine-tRNA synthetase
-
 Oryctolagus cuniculus
6.1.1.6 LysRS
-
 Cricetulus griseus
6.1.1.6 LysRS
-
 Oryctolagus cuniculus
6.1.1.6 Lysyl-transfer ribonucleate synthetase
-
 Cricetulus griseus
6.1.1.6 Lysyl-transfer ribonucleate synthetase
-
 Oryctolagus cuniculus
6.1.1.6 Lysyl-transfer RNA synthetase
-
 Cricetulus griseus
6.1.1.6 Lysyl-transfer RNA synthetase
-
 Oryctolagus cuniculus
6.1.1.6 Lysyl-tRNA synthetase
-
 Cricetulus griseus
6.1.1.6 Lysyl-tRNA synthetase
-
 Oryctolagus cuniculus
6.1.1.6 Synthetase, lysyl-transfer ribonucleate
-
 Cricetulus griseus
6.1.1.6 Synthetase, lysyl-transfer ribonucleate
-
 Oryctolagus cuniculus
6.1.1.15 Global RNA synthesis factor
-
 Cricetulus griseus
6.1.1.15 Pro-tRNA synthetase
-
 Cricetulus griseus
6.1.1.15 Proline translase
-
 Cricetulus griseus
6.1.1.15 Proline--tRNA ligase
-
 Cricetulus griseus
6.1.1.15 Prolyl RNA synthetase
-
 Cricetulus griseus
6.1.1.15 Prolyl-transfer ribonucleate synthetase
-
 Cricetulus griseus
6.1.1.15 Prolyl-transfer ribonucleic acid synthetase
-
 Cricetulus griseus
6.1.1.15 Prolyl-transfer RNA synthetase
-
 Cricetulus griseus
6.1.1.15 Prolyl-tRNA synthetase
-
 Cricetulus griseus
6.1.1.15 ProRS
-
 Cricetulus griseus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
6.1.1.3 37
-
 assay at Cricetulus griseus
6.1.1.3 37
-
 assay at Oryctolagus cuniculus
6.1.1.4 37
-
 assay at Cricetulus griseus
6.1.1.5 37
-
 assay at Cricetulus griseus
6.1.1.5 37
-
 assay at Oryctolagus cuniculus
6.1.1.6 37
-
 assay at Cricetulus griseus
6.1.1.6 37
-
 assay at Oryctolagus cuniculus
6.1.1.15 37
-
 assay at Cricetulus griseus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
6.1.1.3 7.5
-
 assay at Cricetulus griseus
6.1.1.3 7.5
-
 assay at Oryctolagus cuniculus
6.1.1.4 7.5
-
 assay at Cricetulus griseus
6.1.1.5 7.5
-
 assay at Cricetulus griseus
6.1.1.5 7.5
-
 assay at Oryctolagus cuniculus
6.1.1.6 7.5
-
 assay at Cricetulus griseus
6.1.1.6 7.5
-
 assay at Oryctolagus cuniculus
6.1.1.15 7.5
-
 assay at Cricetulus griseus

Cofactor

EC Number Cofactor Comment Organism Structure
6.1.1.3 ATP
-
 Cricetulus griseus
6.1.1.3 ATP
-
 Oryctolagus cuniculus
6.1.1.4 ATP
-
 Cricetulus griseus
6.1.1.5 ATP
-
 Cricetulus griseus
6.1.1.5 ATP
-
 Oryctolagus cuniculus
6.1.1.6 ATP
-
 Cricetulus griseus
6.1.1.6 ATP
-
 Oryctolagus cuniculus
6.1.1.15 ATP
-
 Cricetulus griseus