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Literature summary extracted from
- Plasma hyaluronan-binding protein is a serine protease (2000), J. Biol. Chem., 275, 22978-22985.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.21.B1 | Aprotinin | at high concentrations | Bos taurus |  |
| 3.4.21.B1 | Aprotinin | at high concentrations | Equus sp. | |
| 3.4.21.B1 | Aprotinin | at high concentrations | Homo sapiens | |
| 3.4.21.B1 | Aprotinin | at high concentrations | Oryctolagus cuniculus | |
| 3.4.21.B1 | KPI domain of amyloid-beta precursor protein | complete inhibition at 0.012 mg/ml | Bos taurus | |
| 3.4.21.B1 | KPI domain of amyloid-beta precursor protein | complete inhibition at 0.012 mg/ml | Equus sp. | |
| 3.4.21.B1 | KPI domain of amyloid-beta precursor protein | complete inhibition at 0.012 mg/ml | Homo sapiens | |
| 3.4.21.B1 | KPI domain of amyloid-beta precursor protein | complete inhibition at 0.012 mg/ml | Oryctolagus cuniculus | |
| 3.4.21.B1 | leupeptin | at high concentrations | Bos taurus | |
| 3.4.21.B1 | leupeptin | at high concentrations | Equus sp. | |
| 3.4.21.B1 | leupeptin | at high concentrations | Homo sapiens | |
| 3.4.21.B1 | leupeptin | at high concentrations | Oryctolagus cuniculus | |
| 3.4.21.B1 | phenylmethylsulfonyl fluoride | at high concentrations | Bos taurus | |
| 3.4.21.B1 | phenylmethylsulfonyl fluoride | at high concentrations | Equus sp. | |
| 3.4.21.B1 | phenylmethylsulfonyl fluoride | at high concentrations | Homo sapiens | |
| 3.4.21.B1 | phenylmethylsulfonyl fluoride | at high concentrations | Oryctolagus cuniculus | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 3.4.21.B1 | 30000 | - |
1 * 44000 + 1 * 30000, SDS-PAGE with 2-mercaptoethanol | Homo sapiens |
| 3.4.21.B1 | 30000 | - |
1 * 44000 + 1 * 30000, SDS-PAGE with 2-mercaptoethanol | Bos taurus |
| 3.4.21.B1 | 30000 | - |
1 * 44000 + 1 * 30000, SDS-PAGE with 2-mercaptoethanol | Oryctolagus cuniculus |
| 3.4.21.B1 | 30000 | - |
1 * 44000 + 1 * 30000, SDS-PAGE with 2-mercaptoethanol | Equus sp. |
| 3.4.21.B1 | 44000 | - |
1 * 44000 + 1 * 30000, SDS-PAGE with 2-mercaptoethanol | Homo sapiens |
| 3.4.21.B1 | 44000 | - |
1 * 44000 + 1 * 30000, SDS-PAGE with 2-mercaptoethanol | Bos taurus |
| 3.4.21.B1 | 44000 | - |
1 * 44000 + 1 * 30000, SDS-PAGE with 2-mercaptoethanol | Oryctolagus cuniculus |
| 3.4.21.B1 | 44000 | - |
1 * 44000 + 1 * 30000, SDS-PAGE with 2-mercaptoethanol | Equus sp. |
| 3.4.21.B1 | 70000 | - |
proenzyme | Homo sapiens |
| 3.4.21.B1 | 70000 | - |
proenzyme | Bos taurus |
| 3.4.21.B1 | 70000 | - |
proenzyme | Oryctolagus cuniculus |
| 3.4.21.B1 | 70000 | - |
proenzyme | Equus sp. |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.21.B1 | Protein + H2O | Homo sapiens | - |
? | - |
? | |
| 3.4.21.B1 | Protein + H2O | Bos taurus | - |
? | - |
? | |
| 3.4.21.B1 | Protein + H2O | Oryctolagus cuniculus | - |
? | - |
? | |
| 3.4.21.B1 | Protein + H2O | Equus sp. | - |
? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.21.B1 | Bos taurus | - |
- |
- |
| 3.4.21.B1 | Equus sp. | - |
- |
- |
| 3.4.21.B1 | Homo sapiens | - |
- |
- |
| 3.4.21.B1 | Oryctolagus cuniculus | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.4.21.B1 | homogeneity | Homo sapiens |
| 3.4.21.B1 | homogeneity | Bos taurus |
| 3.4.21.B1 | homogeneity | Oryctolagus cuniculus |
| 3.4.21.B1 | homogeneity | Equus sp. |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.21.B1 | plasma | - |
Homo sapiens | - |
| 3.4.21.B1 | plasma | - |
Bos taurus | - |
| 3.4.21.B1 | plasma | - |
Oryctolagus cuniculus | - |
| 3.4.21.B1 | plasma | - |
Equus sp. | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.21.B1 | CTCF + H2O | essential factor for optimal transcription from the amyloid beta-protein precursor promoter, enzyme cleaves CTCF at three major sites | Homo sapiens | ? | - |
? | |
| 3.4.21.B1 | CTCF + H2O | essential factor for optimal transcription from the amyloid beta-protein precursor promoter, enzyme cleaves CTCF at three major sites | Bos taurus | ? | - |
? | |
| 3.4.21.B1 | CTCF + H2O | essential factor for optimal transcription from the amyloid beta-protein precursor promoter, enzyme cleaves CTCF at three major sites | Oryctolagus cuniculus | ? | - |
? | |
| 3.4.21.B1 | CTCF + H2O | essential factor for optimal transcription from the amyloid beta-protein precursor promoter, enzyme cleaves CTCF at three major sites | Equus sp. | ? | - |
? | |
| 3.4.21.B1 | Protein + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.B1 | Protein + H2O | - |
Bos taurus | ? | - |
? | |
| 3.4.21.B1 | Protein + H2O | - |
Oryctolagus cuniculus | ? | - |
? | |
| 3.4.21.B1 | Protein + H2O | - |
Equus sp. | ? | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 3.4.21.B1 | dimer | 1 * 44000 + 1 * 30000, SDS-PAGE with 2-mercaptoethanol | Homo sapiens |
| 3.4.21.B1 | dimer | 1 * 44000 + 1 * 30000, SDS-PAGE with 2-mercaptoethanol | Bos taurus |
| 3.4.21.B1 | dimer | 1 * 44000 + 1 * 30000, SDS-PAGE with 2-mercaptoethanol | Oryctolagus cuniculus |
| 3.4.21.B1 | dimer | 1 * 44000 + 1 * 30000, SDS-PAGE with 2-mercaptoethanol | Equus sp. |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.21.B1 | PHBP | - |
Homo sapiens |
| 3.4.21.B1 | PHBP | - |
Bos taurus |
| 3.4.21.B1 | PHBP | - |
Oryctolagus cuniculus |
| 3.4.21.B1 | PHBP | - |
Equus sp. |
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