Any feedback?
Literature summary extracted from
- Selective inhibition of trypsin by (2R,4R)-4-phenyl-1-[Nalpha-(7-methoxy-2-naphthalenesulfonyl)-L-arginyl]-2-piperidinecarboxylic acid (2000), J. Biol. Chem., 275, 18995-18999.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.21.4 | (2R,4R)-4-phenyl-1-[Nalpha-(7-methoxy-2-naphthalenesulfonyl)-L-arginyl]-2-piperidinecarboxylic acid | competitive, small molecular weight inhibitor without tryptase inhibitor activity | Bos taurus |  |
| 3.4.21.4 | 1-[N2-[(7-methoxynaphthalen-2-yl)sulfonyl]-L-arginyl]-4-phenylpiperidine-2-carboxylic acid | IC50: 0.0003 mM | Bos taurus | |
| 3.4.21.4 | antipain | IC50: 0.04 mM | Bos taurus | |
| 3.4.21.4 | leupeptin | IC50: 0.0002 mM | Bos taurus | |
| 3.4.21.4 | nafamostat mesilate | IC50: 0.00003 mM | Bos taurus | |
| 3.4.21.4 | Soybean trypsin inhibitor | IC50: 0.000009 mM | Bos taurus |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.21.4 | Bos taurus | P00760 | - |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.21.4 | pancreas | - |
Bos taurus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.21.4 | D-Phe-Pip-Arg 4-nitroanilide + H2O | - |
Bos taurus | ? | - |
? | |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.4.21.4 | 0.0001 | - |
(2R,4R)-4-phenyl-1-[Nalpha-(7-methoxy-2-naphthalenesulfonyl)-L-arginyl]-2-piperidinecarboxylic acid | pH 8.1, 37°C | Bos taurus | |
IC50 Value
| EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|---|
| 3.4.21.4 | 0.000009 | - |
IC50: 0.000009 mM | Bos taurus | Soybean trypsin inhibitor | |
| 3.4.21.4 | 0.00003 | - |
IC50: 0.00003 mM | Bos taurus | nafamostat mesilate | |
| 3.4.21.4 | 0.0002 | - |
IC50: 0.0002 mM | Bos taurus | leupeptin | |
| 3.4.21.4 | 0.0003 | - |
IC50: 0.0003 mM | Bos taurus | 1-[N2-[(7-methoxynaphthalen-2-yl)sulfonyl]-L-arginyl]-4-phenylpiperidine-2-carboxylic acid | |
| 3.4.21.4 | 0.04 | - |
IC50: 0.04 mM | Bos taurus | antipain | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
