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Literature summary extracted from

  • Barmina, O.Y.; Walling, H.W.; Fiacco, G.J.; Freije, J.M.; Lopez-Otin, C.; Jeffrey, J.J.; Partridge, N.C.
    Collagenase-3 binds to a specific receptor and requires the low density lipoprotein receptor-related protein for internalization (1999), J. Biol. Chem., 274, 30087-30093.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.24.B4 extracellular secretion Rattus norvegicus
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.24.B4 additional information Ca2+-dependent binding to the specific receptor of osteoblastic and fibroblastic cell lines via residue I125 Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.B4 additional information Rattus norvegicus osteoblastic osteosarcoma cell line UMR 106-01, Ca2+-dependent binding in a two-step mechanism via the required specific 170 kDa enzyme receptor and the required 600 kDa LDL-receptor, internalization and degradation of the enzyme, modeling, the enzyme also binds to mouse fibroblastic cells ?
-
?
3.4.24.B4 protein + H2O Rattus norvegicus
-
peptides
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.B4 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.24.B4 purification of the secreted enzyme from the cell culture medium Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.B4 cell culture uterine smooth muscle cells Rattus norvegicus
-
3.4.24.B4 additional information osteoblastic osteosarcoma cell line UMR 106-01, Ca2+-dependent binding in a two-step mechanism via the required specific enzyme receptor and LDL-receptor-related protein, internalization and degradation of the enzyme, also binding to fibroblastic cells Rattus norvegicus
-
3.4.24.B4 smooth muscle
-
Rattus norvegicus
-
3.4.24.B4 uterus
-
Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.B4 additional information osteoblastic osteosarcoma cell line UMR 106-01, Ca2+-dependent binding in a two-step mechanism via the required specific 170 kDa enzyme receptor and the required 600 kDa LDL-receptor, internalization and degradation of the enzyme, modeling, the enzyme also binds to mouse fibroblastic cells Rattus norvegicus ?
-
?
3.4.24.B4 protein + H2O
-
Rattus norvegicus peptides
-
?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.B4 M10.013 Merops-ID Rattus norvegicus
3.4.24.B4 matrix metalloproteinase-13
-
Rattus norvegicus
3.4.24.B4 MMP-13
-
Rattus norvegicus