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Literature summary extracted from

  • Savel'ev, A.S.; Novikova, L.A.; Kovaleva, I.E.; Luzikov, V.N.; Neupert, W.; Langer, T.
    ATP-dependent proteolysis in mitochondria. m-AAA protease and PIM1 protease exert overlapping substrate specificities and cooperate with the mtHsp70 system (1998), J. Biol. Chem., 273, 20596-20602.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
3.4.24.B18 E559Q inactive mutant Saccharomyces cerevisiae
3.4.24.B18 E614Q inactive mutant Saccharomyces cerevisiae

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.21.53 mitochondrion
-
 Saccharomyces cerevisiae 5739
-
3.4.24.B18 membrane
-
 Saccharomyces cerevisiae 16020
-
3.4.24.B18 mitochondrion
-
 Saccharomyces cerevisiae 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.B18 protein + H2O Saccharomyces cerevisiae degradation of mislocalized proteins in the mitochodria peptides
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.53 Saccharomyces cerevisiae
-
 yeast
-
3.4.24.B18 Saccharomyces cerevisiae
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
3.4.24.B18 proteolytic degradation of proteins enzyme shows overlapping substrate specificity with the ATP-dependent PIM1 protease located in the mitochondrial matrix Saccharomyces cerevisiae
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.53 bovine apocytochrome P450scc + H2O
-
 Saccharomyces cerevisiae ?
-
 ?
3.4.24.B18 apocytochrome P450scc + H2O bovine protein substrate from adrenal cortex mitochondrial inner membrane, imported in vitro into isolated yeast mitochondrial membrane, due to an N-terminal fusion to a heterologous transmembrane region Saccharomyces cerevisiae ?
-
 ?
3.4.24.B18 protein + H2O
-
 Saccharomyces cerevisiae peptides
-
 ?
3.4.24.B18 protein + H2O degradation of mislocalized proteins in the mitochodria Saccharomyces cerevisiae peptides
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.53 lon-like protease
-
 Saccharomyces cerevisiae
3.4.21.53 PIM1 protease
-
 Saccharomyces cerevisiae
3.4.24.B18 M41.003 Merops-ID Saccharomyces cerevisiae

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.24.B18 37
-
 assay at Saccharomyces cerevisiae

Cofactor

EC Number Cofactor Comment Organism Structure
3.4.21.53 ATP
-
 Saccharomyces cerevisiae