EC Number | Cloned (Comment) | Organism |
---|---|---|
3.4.11.1 | expression in COS-7 and in CHO cells, secretion from recombinant COS-7 cells | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.4.11.1 | amastatin | - |
Homo sapiens | |
3.4.11.1 | Zn2+ | - |
Homo sapiens |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.4.11.1 | 1.28 | - |
Leu-4-nitroanilide | - |
Homo sapiens |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
3.4.11.1 | Zinc | zinc-metallopeptidase, contains the HEXXH motif | Homo sapiens |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
3.4.11.1 | 106000 | - |
1 * 106000, recombinant enzyme, SDS-PAGE | Homo sapiens |
3.4.11.1 | 120000 | - |
recombinant enzyme from CHO cells, gel filtration | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.11.1 | angiotensin II + H2O | Homo sapiens | - |
angiotensin IV + ? | through angiotensin III | ? | |
3.4.11.1 | kallidin + H2O | Homo sapiens | i.e. LRPPGFSPFR | Leu + bradykinin | i.e. RPPGFSPFR | ? | |
3.4.11.1 | additional information | Homo sapiens | broad substrate specificity towards naturally occurring peptide hormones, while the enzyme hydrolyzes synthetic substrate in vitro with specificity for leucine, enzyme plays a role in regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.11.1 | Homo sapiens | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
3.4.11.1 | recombinant from CHO cells, 5fold to homogeneity | Homo sapiens |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.4.11.1 | adipocyte | - |
Homo sapiens | - |
3.4.11.1 | kidney | cortex | Homo sapiens | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
3.4.11.1 | 0.192 | - |
purified recombinant enzyme | Homo sapiens |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.11.1 | angiotensin II + H2O | - |
Homo sapiens | angiotensin IV + ? | through angiotensin III | ? | |
3.4.11.1 | dynorphin A + H2O | - |
Homo sapiens | ? | - |
? | |
3.4.11.1 | kallidin + H2O | i.e. LRPPGFSPFR | Homo sapiens | Leu + bradykinin | i.e. RPPGFSPFR | ? | |
3.4.11.1 | Leu-4-nitroanilide + H2O | - |
Homo sapiens | Leu + 4-nitroaniline | - |
? | |
3.4.11.1 | additional information | broad substrate specificity towards naturally occurring peptide hormones, while the enzyme hydrolyzes synthetic substrate in vitro with specificity for leucine, enzyme plays a role in regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney | Homo sapiens | ? | - |
? | |
3.4.11.1 | Neurokinin A + H2O | - |
Homo sapiens | ? | - |
? | |
3.4.11.1 | Neuromedin B + H2O | - |
Homo sapiens | ? | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
3.4.11.1 | monomer | 1 * 106000, recombinant enzyme, SDS-PAGE | Homo sapiens |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.4.11.1 | A-LAP | - |
Homo sapiens |
3.4.11.1 | adipocyte-derived leucine aminopeptidase | - |
Homo sapiens |
3.4.11.1 | aminopeptidase I | - |
Homo sapiens |
3.4.11.1 | aminopeptidase II | - |
Homo sapiens |
3.4.11.1 | Aminopeptidase III | - |
Homo sapiens |
3.4.11.1 | cathepsin III | - |
Homo sapiens |
3.4.11.1 | cytosol aminopeptidase | - |
Homo sapiens |
3.4.11.1 | FTBL protein | - |
Homo sapiens |
3.4.11.1 | L-leucine aminopeptidase | - |
Homo sapiens |
3.4.11.1 | leucinamide aminopeptidase | - |
Homo sapiens |
3.4.11.1 | leucinaminopeptidase | - |
Homo sapiens |
3.4.11.1 | leucine aminopeptidase | - |
Homo sapiens |
3.4.11.1 | leucyl peptidase | - |
Homo sapiens |
3.4.11.1 | More | enzyme belongs to the peptidase family M17, enzyme belongs to the metallopeptidase family M1 | Homo sapiens |
3.4.11.1 | peptidase S | - |
Homo sapiens |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
3.4.11.1 | 7.5 | - |
- |
Homo sapiens |
EC Number | pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|---|
3.4.11.1 | additional information | - |
pH profile | Homo sapiens |