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Literature summary extracted from

  • Shofuda, K.I.; Moriyama, K.; Nishihashi, A.; Higashi, S.; Mizushima, H.; Yasumitsu, H.; Miki, K.; Sato, H.; Seiki, M.; Miyazaki, K.
    Role of tissue inhibitor of metalloproteinases-2 (TIMP-2) in regulation of pro-gelatinase A activation catalyzed by membrane-type matrix metalloproteinase-1 (MT1-MMP) in human cancer cells (1998), J. Biochem., 124, 462-470.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.24.B5 12-O-tetradecanoyl phorbol 13-acetate activates enzyme expression Homo sapiens
3.4.24.B5 concanavalin A regulatory role, activates enzyme expression and activity, effect is inhibited by matrix metalloproteinase inhibitor TIMP-2 Homo sapiens
3.4.24.B5 tissue matrix metalloprotease inhibitor TIMP-2 regulatory role, expression and protein levels in cancer cell lines are not corresponding, overview Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.B5 matrix metalloproteinase inhibitor TIMP-2 regulatory function, forms complex with the enzyme on the surface of cells Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.24.B5 membrane on the cell surface Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.B5 protein + H2O Homo sapiens
-
 peptides
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.B5 Homo sapiens
-
 membrane-type-1, -type-2 and -type-3 matrix metalloproteases
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.B5 G-361 cell cancer cell line, low expression of MT2 MMP Homo sapiens
-
3.4.24.B5 HeLa-S3 cell cancer cell line, expressing the proform gelatinase A, concanavalin A induces MT2 MMP expression Homo sapiens
-
3.4.24.B5 HSC-3 cell squamous carcinoma cell line, expresssion of MT2 MMP not MT1 MMP and MT3 MMP Homo sapiens
-
3.4.24.B5 HSC-4 cell squamous carcinoma cell line, expresssion of MT2 MMP not MT1 MMP and MT3 MMP Homo sapiens
-
3.4.24.B5 HT-1080 cell expresssion of MT2 MMP not MT1 MMP and MT3 MMP, cancer cell line, expressing the proform gelatinase A, concanavalin A supresses the expression of MT1 MMP Homo sapiens
-
3.4.24.B5 T-24 cell cancer cell line, low expression of MT2 MMP Homo sapiens
-
3.4.24.B5 T-98G cell cancer cell line, low expression of MT2 MMP Homo sapiens
-
3.4.24.B5 U-87MG cell cancer cell line, low expression of MT2 MMP and expression of MT3 MMP Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.B5 progelatinase A + H2O substrate is activated by cleavage Homo sapiens gelatinase A + ?
-
 ?
3.4.24.B5 protein + H2O
-
 Homo sapiens peptides
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.B5 M10.015 Merops-ID Homo sapiens
3.4.24.B5 membrane-type-1 matrix metalloproteinase
-
 Homo sapiens
3.4.24.B5 membrane-type-2 matrix metalloproteinase
-
 Homo sapiens
3.4.24.B5 membrane-type-3 matrix metalloproteinase
-
 Homo sapiens
3.4.24.B5 MT1 MMP
-
 Homo sapiens
3.4.24.B5 MT2 MMP
-
 Homo sapiens