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Literature summary extracted from
- Membrane protein degradation by FtsH can be initiated from either end (2002), J. Bacteriol., 184, 4775-4782.
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.4.24.B17 | membrane | integral | Escherichia coli | 16020 | - |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.24.B17 | protein + H2O | Escherichia coli | - |
peptides | - |
? |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.24.B17 | Escherichia coli | - |
- |
- |
Reaction
| EC Number | Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|---|
| 3.4.24.B17 | proteolytic degradation of proteins | mechanism | Escherichia coli |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.24.B17 | chimeric protein PhoA-TM8-C30 + H2O | recombinant substrate protein consists of one transmembrane segment of protein SecY, i.e. TM8, plus the following 30 residues of a cytoplasmic part, and the C-terminal end of alkaline phosphatase PhoA | Escherichia coli | ? | - |
? | |
| 3.4.24.B17 | fusion protein SecY-(P5)-PhoA + H2O | recombinant substrate protein consists of one protein SecY without its C-terminus, and the alkaline phosphatase PhoA | Escherichia coli | ? | - |
? | |
| 3.4.24.B17 | protein + H2O | - |
Escherichia coli | peptides | - |
? | |
| 3.4.24.B17 | protein + H2O | substrate specificity, soluble and integral membrane proteins, initiation of degradation by recognition and binding of more than 20 amino acids of the C-terminal cytosolic tail of the substrate, subsequently the substrate can be dislocated into the cytosol or degraded simultaneously bidirectionally | Escherichia coli | peptides | - |
? | |
| 3.4.24.B17 | protein SecY + H2O | - |
Escherichia coli | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.24.B17 | FtsH | - |
Escherichia coli |
| 3.4.24.B17 | M41.001 | Merops-ID | Escherichia coli |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.24.B17 | ATP | dependent on | Escherichia coli | |
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Release 2023.1 (January 2023)
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