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Literature summary extracted from

  • Mahapatra, S.; Crick, D.C.; Brennan, P.J.
    Comparison of the UDP-N-acetylmuramate:L-alanine ligase enzymes from Mycobacterium tuberculosis and Mycobacterium leprae (2000), J. Bacteriol., 182, 6827-6830.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
6.3.2.8 expressed in Escherichia coli BL21(DE3) Mycobacterium leprae
6.3.2.8 expressed in Escherichia coli BL21(DE3) Mycobacterium tuberculosis

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
6.3.2.8 0.01
-
 L-alanine pH 8.6 Mycobacterium leprae
6.3.2.8 0.014
-
 L-alanine pH 8.6 Mycobacterium tuberculosis
6.3.2.8 0.0258
-
 glycine pH 8.6 Mycobacterium leprae
6.3.2.8 0.038
-
 glycine pH 8.6 Mycobacterium tuberculosis

Organism

EC Number Organism UniProt Comment Textmining
6.3.2.8 Mycobacterium leprae
-
-
-
6.3.2.8 Mycobacterium tuberculosis
-
-
-
6.3.2.8 Mycobacterium tuberculosis H37Rv
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.2.8 ATP + UDP-N-acetylmuramate + glycine
-
 Mycobacterium leprae ADP + phosphate + UDP-N-acetylmuramoyl-glycine
-
 r
6.3.2.8 ATP + UDP-N-acetylmuramate + glycine
-
 Mycobacterium tuberculosis ADP + phosphate + UDP-N-acetylmuramoyl-glycine
-
 r
6.3.2.8 ATP + UDP-N-acetylmuramate + glycine
-
 Mycobacterium tuberculosis H37Rv ADP + phosphate + UDP-N-acetylmuramoyl-glycine
-
 r
6.3.2.8 ATP + UDP-N-acetylmuramate + L-alanine
-
 Mycobacterium leprae ADP + phosphate + UDP-N-acetylmuramoyl-L-alanine
-
 r
6.3.2.8 ATP + UDP-N-acetylmuramate + L-alanine
-
 Mycobacterium tuberculosis ADP + phosphate + UDP-N-acetylmuramoyl-L-alanine
-
 r
6.3.2.8 ATP + UDP-N-acetylmuramate + L-alanine
-
 Mycobacterium tuberculosis H37Rv ADP + phosphate + UDP-N-acetylmuramoyl-L-alanine
-
 r