Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Menendez, C.; Bauer, Z.; Huber, H.; Gad'on, N.; Stetter, K.O.; Fuchs, G.
    Presence of acetyl coenzyme A (CoA) carboxylase and propionyl-CoA carboxylase in autotrophic Crenarchaeota and indication for operation of a 3-hydroxypropionate cycle in autotrophic carbon fixation (1999), J. Bacteriol., 181, 1088-1098.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.4.1.2 Avidin complete inhibition at 1 nM Metallosphaera sedula

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
6.4.1.2 Mg2+ complex with ATP Chloroflexus aurantiacus
6.4.1.2 Mg2+ complex with ATP Metallosphaera sedula
6.4.1.2 Mg2+ complex with ATP Sulfuracidifex metallicus
6.4.1.2 Mg2+ complex with ATP Acidianus infernus
6.4.1.3 Mg2+ required Chloroflexus aurantiacus
6.4.1.3 Mg2+ required Metallosphaera sedula
6.4.1.3 Mg2+ required Sulfuracidifex metallicus
6.4.1.3 Mg2+ required Acidianus infernus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.4.1.2 ATP + acetyl-CoA + HCO3- Chloroflexus aurantiacus no fatty acid synthesis, involved in 3-hydroxypropionate cycle for autotrophic CO2 fixation ADP + phosphate + malonyl-CoA
-
 ?
6.4.1.2 ATP + acetyl-CoA + HCO3- Metallosphaera sedula no fatty acid synthesis, involved in 3-hydroxypropionate cycle for autotrophic CO2 fixation ADP + phosphate + malonyl-CoA
-
 ?
6.4.1.2 ATP + acetyl-CoA + HCO3- Sulfuracidifex metallicus no fatty acid synthesis, involved in 3-hydroxypropionate cycle for autotrophic CO2 fixation ADP + phosphate + malonyl-CoA
-
 ?
6.4.1.2 ATP + acetyl-CoA + HCO3- Acidianus infernus no fatty acid synthesis, involved in 3-hydroxypropionate cycle for autotrophic CO2 fixation ADP + phosphate + malonyl-CoA
-
 ?
6.4.1.2 ATP + acetyl-CoA + HCO3- Acidianus infernus So4a / DSM 3191 no fatty acid synthesis, involved in 3-hydroxypropionate cycle for autotrophic CO2 fixation ADP + phosphate + malonyl-CoA
-
 ?
6.4.1.2 ATP + acetyl-CoA + HCO3- Sulfuracidifex metallicus Kra23 / DSM 6482 no fatty acid synthesis, involved in 3-hydroxypropionate cycle for autotrophic CO2 fixation ADP + phosphate + malonyl-CoA
-
 ?
6.4.1.2 ATP + acetyl-CoA + HCO3- Metallosphaera sedula TH2 / ATCC 51363 / DSM 5348 no fatty acid synthesis, involved in 3-hydroxypropionate cycle for autotrophic CO2 fixation ADP + phosphate + malonyl-CoA
-
 ?
6.4.1.2 ATP + acetyl-CoA + HCO3- Chloroflexus aurantiacus OK-70-fl / DSM 636 no fatty acid synthesis, involved in 3-hydroxypropionate cycle for autotrophic CO2 fixation ADP + phosphate + malonyl-CoA
-
 ?
6.4.1.3 ATP + propanoyl-CoA + HCO3- Chloroflexus aurantiacus CO2 fixation during autotrophic growth, enzyme of the 3-hydroxypropionate cycle ADP + phosphate + (S)-methylmalonyl-CoA
-
 ?
6.4.1.3 ATP + propanoyl-CoA + HCO3- Metallosphaera sedula CO2 fixation during autotrophic growth, enzyme of the 3-hydroxypropionate cycle ADP + phosphate + (S)-methylmalonyl-CoA
-
 ?
6.4.1.3 ATP + propanoyl-CoA + HCO3- Sulfuracidifex metallicus CO2 fixation during autotrophic growth, enzyme of the 3-hydroxypropionate cycle ADP + phosphate + (S)-methylmalonyl-CoA
-
 ?
6.4.1.3 ATP + propanoyl-CoA + HCO3- Acidianus infernus CO2 fixation during autotrophic growth, enzyme of the 3-hydroxypropionate cycle ADP + phosphate + (S)-methylmalonyl-CoA
-
 ?
6.4.1.3 ATP + propanoyl-CoA + HCO3- Acidianus infernus So4a / DSM 3191 CO2 fixation during autotrophic growth, enzyme of the 3-hydroxypropionate cycle ADP + phosphate + (S)-methylmalonyl-CoA
-
 ?
6.4.1.3 ATP + propanoyl-CoA + HCO3- Sulfuracidifex metallicus Kra23 / DSM 6482 CO2 fixation during autotrophic growth, enzyme of the 3-hydroxypropionate cycle ADP + phosphate + (S)-methylmalonyl-CoA
-
 ?
6.4.1.3 ATP + propanoyl-CoA + HCO3- Metallosphaera sedula TH2 / ATCC 51363 / DSM 5348 CO2 fixation during autotrophic growth, enzyme of the 3-hydroxypropionate cycle ADP + phosphate + (S)-methylmalonyl-CoA
-
 ?
6.4.1.3 ATP + propanoyl-CoA + HCO3- Chloroflexus aurantiacus OK-70-fl / DSM 636 CO2 fixation during autotrophic growth, enzyme of the 3-hydroxypropionate cycle ADP + phosphate + (S)-methylmalonyl-CoA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.4.1.2 Acidianus infernus
-
-
-
6.4.1.2 Acidianus infernus So4a / DSM 3191
-
-
-
6.4.1.2 Chloroflexus aurantiacus
-
-
-
6.4.1.2 Chloroflexus aurantiacus OK-70-fl / DSM 636
-
-
-
6.4.1.2 Metallosphaera sedula
-
-
-
6.4.1.2 Metallosphaera sedula TH2 / ATCC 51363 / DSM 5348
-
-
-
6.4.1.2 Sulfuracidifex metallicus
-
-
-
6.4.1.2 Sulfuracidifex metallicus Kra23 / DSM 6482
-
-
-
6.4.1.3 Acidianus infernus
-
-
-
6.4.1.3 Acidianus infernus So4a / DSM 3191
-
-
-
6.4.1.3 Chloroflexus aurantiacus
-
-
-
6.4.1.3 Chloroflexus aurantiacus OK-70-fl / DSM 636
-
-
-
6.4.1.3 Metallosphaera sedula
-
-
-
6.4.1.3 Metallosphaera sedula TH2 / ATCC 51363 / DSM 5348
-
-
-
6.4.1.3 Sulfuracidifex metallicus
-
-
-
6.4.1.3 Sulfuracidifex metallicus Kra23 / DSM 6482
-
-
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
6.4.1.2 0.0002
-
 crude extract, pH 7.8, 60°C Acidianus infernus
6.4.1.2 0.0025
-
 crude extract, pH 7.8, 60°C Sulfuracidifex metallicus
6.4.1.2 0.013
-
 crude extract, pH 7.8, 55°C Metallosphaera sedula
6.4.1.2 0.015
-
 crude extract, pH 7.8, 55°C Chloroflexus aurantiacus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.4.1.2 ATP + acetyl-CoA + HCO3-
-
 Chloroflexus aurantiacus ADP + phosphate + malonyl-CoA
-
 ?
6.4.1.2 ATP + acetyl-CoA + HCO3-
-
 Metallosphaera sedula ADP + phosphate + malonyl-CoA
-
 ?
6.4.1.2 ATP + acetyl-CoA + HCO3-
-
 Sulfuracidifex metallicus ADP + phosphate + malonyl-CoA
-
 ?
6.4.1.2 ATP + acetyl-CoA + HCO3-
-
 Acidianus infernus ADP + phosphate + malonyl-CoA
-
 ?
6.4.1.2 ATP + acetyl-CoA + HCO3- no fatty acid synthesis, involved in 3-hydroxypropionate cycle for autotrophic CO2 fixation Chloroflexus aurantiacus ADP + phosphate + malonyl-CoA
-
 ?
6.4.1.2 ATP + acetyl-CoA + HCO3- no fatty acid synthesis, involved in 3-hydroxypropionate cycle for autotrophic CO2 fixation Metallosphaera sedula ADP + phosphate + malonyl-CoA
-
 ?
6.4.1.2 ATP + acetyl-CoA + HCO3- no fatty acid synthesis, involved in 3-hydroxypropionate cycle for autotrophic CO2 fixation Sulfuracidifex metallicus ADP + phosphate + malonyl-CoA
-
 ?
6.4.1.2 ATP + acetyl-CoA + HCO3- no fatty acid synthesis, involved in 3-hydroxypropionate cycle for autotrophic CO2 fixation Acidianus infernus ADP + phosphate + malonyl-CoA
-
 ?
6.4.1.2 ATP + acetyl-CoA + HCO3-
-
 Acidianus infernus So4a / DSM 3191 ADP + phosphate + malonyl-CoA
-
 ?
6.4.1.2 ATP + acetyl-CoA + HCO3- no fatty acid synthesis, involved in 3-hydroxypropionate cycle for autotrophic CO2 fixation Acidianus infernus So4a / DSM 3191 ADP + phosphate + malonyl-CoA
-
 ?
6.4.1.2 ATP + acetyl-CoA + HCO3-
-
 Sulfuracidifex metallicus Kra23 / DSM 6482 ADP + phosphate + malonyl-CoA
-
 ?
6.4.1.2 ATP + acetyl-CoA + HCO3- no fatty acid synthesis, involved in 3-hydroxypropionate cycle for autotrophic CO2 fixation Sulfuracidifex metallicus Kra23 / DSM 6482 ADP + phosphate + malonyl-CoA
-
 ?
6.4.1.2 ATP + acetyl-CoA + HCO3-
-
 Metallosphaera sedula TH2 / ATCC 51363 / DSM 5348 ADP + phosphate + malonyl-CoA
-
 ?
6.4.1.2 ATP + acetyl-CoA + HCO3- no fatty acid synthesis, involved in 3-hydroxypropionate cycle for autotrophic CO2 fixation Metallosphaera sedula TH2 / ATCC 51363 / DSM 5348 ADP + phosphate + malonyl-CoA
-
 ?
6.4.1.2 ATP + acetyl-CoA + HCO3-
-
 Chloroflexus aurantiacus OK-70-fl / DSM 636 ADP + phosphate + malonyl-CoA
-
 ?
6.4.1.2 ATP + acetyl-CoA + HCO3- no fatty acid synthesis, involved in 3-hydroxypropionate cycle for autotrophic CO2 fixation Chloroflexus aurantiacus OK-70-fl / DSM 636 ADP + phosphate + malonyl-CoA
-
 ?
6.4.1.3 ATP + propanoyl-CoA + HCO3-
-
 Chloroflexus aurantiacus ADP + phosphate + (S)-methylmalonyl-CoA
-
 ?
6.4.1.3 ATP + propanoyl-CoA + HCO3-
-
 Metallosphaera sedula ADP + phosphate + (S)-methylmalonyl-CoA
-
 ?
6.4.1.3 ATP + propanoyl-CoA + HCO3-
-
 Sulfuracidifex metallicus ADP + phosphate + (S)-methylmalonyl-CoA
-
 ?
6.4.1.3 ATP + propanoyl-CoA + HCO3-
-
 Acidianus infernus ADP + phosphate + (S)-methylmalonyl-CoA
-
 ?
6.4.1.3 ATP + propanoyl-CoA + HCO3- CO2 fixation during autotrophic growth, enzyme of the 3-hydroxypropionate cycle Chloroflexus aurantiacus ADP + phosphate + (S)-methylmalonyl-CoA
-
 ?
6.4.1.3 ATP + propanoyl-CoA + HCO3- CO2 fixation during autotrophic growth, enzyme of the 3-hydroxypropionate cycle Metallosphaera sedula ADP + phosphate + (S)-methylmalonyl-CoA
-
 ?
6.4.1.3 ATP + propanoyl-CoA + HCO3- CO2 fixation during autotrophic growth, enzyme of the 3-hydroxypropionate cycle Sulfuracidifex metallicus ADP + phosphate + (S)-methylmalonyl-CoA
-
 ?
6.4.1.3 ATP + propanoyl-CoA + HCO3- CO2 fixation during autotrophic growth, enzyme of the 3-hydroxypropionate cycle Acidianus infernus ADP + phosphate + (S)-methylmalonyl-CoA
-
 ?
6.4.1.3 ATP + propanoyl-CoA + HCO3-
-
 Acidianus infernus So4a / DSM 3191 ADP + phosphate + (S)-methylmalonyl-CoA
-
 ?
6.4.1.3 ATP + propanoyl-CoA + HCO3- CO2 fixation during autotrophic growth, enzyme of the 3-hydroxypropionate cycle Acidianus infernus So4a / DSM 3191 ADP + phosphate + (S)-methylmalonyl-CoA
-
 ?
6.4.1.3 ATP + propanoyl-CoA + HCO3-
-
 Sulfuracidifex metallicus Kra23 / DSM 6482 ADP + phosphate + (S)-methylmalonyl-CoA
-
 ?
6.4.1.3 ATP + propanoyl-CoA + HCO3- CO2 fixation during autotrophic growth, enzyme of the 3-hydroxypropionate cycle Sulfuracidifex metallicus Kra23 / DSM 6482 ADP + phosphate + (S)-methylmalonyl-CoA
-
 ?
6.4.1.3 ATP + propanoyl-CoA + HCO3-
-
 Metallosphaera sedula TH2 / ATCC 51363 / DSM 5348 ADP + phosphate + (S)-methylmalonyl-CoA
-
 ?
6.4.1.3 ATP + propanoyl-CoA + HCO3- CO2 fixation during autotrophic growth, enzyme of the 3-hydroxypropionate cycle Metallosphaera sedula TH2 / ATCC 51363 / DSM 5348 ADP + phosphate + (S)-methylmalonyl-CoA
-
 ?
6.4.1.3 ATP + propanoyl-CoA + HCO3-
-
 Chloroflexus aurantiacus OK-70-fl / DSM 636 ADP + phosphate + (S)-methylmalonyl-CoA
-
 ?
6.4.1.3 ATP + propanoyl-CoA + HCO3- CO2 fixation during autotrophic growth, enzyme of the 3-hydroxypropionate cycle Chloroflexus aurantiacus OK-70-fl / DSM 636 ADP + phosphate + (S)-methylmalonyl-CoA
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
6.4.1.2 biotin enzyme-bound Chloroflexus aurantiacus
6.4.1.2 biotin enzyme-bound Metallosphaera sedula
6.4.1.2 biotin enzyme-bound Sulfuracidifex metallicus
6.4.1.2 biotin enzyme-bound Acidianus infernus
6.4.1.3 biotin bound to enzyme Chloroflexus aurantiacus
6.4.1.3 biotin bound to enzyme Metallosphaera sedula
6.4.1.3 biotin bound to enzyme Sulfuracidifex metallicus
6.4.1.3 biotin bound to enzyme Acidianus infernus