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Literature summary extracted from

  • Moncada, D.; Keller, K.; Chadee, K.
    Entamoeba histolytica cysteine proteinases disrupt the polymeric structure of colonic mucin and alter its protective function (2003), Infect. Immun., 71, 838-844.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.22.35 cystatin
-
 Entamoeba histolytica
3.4.22.35 leupeptin
-
 Entamoeba histolytica
3.4.22.35 additional information no inhibition by aprotinin, pepstatin, phosphoramidon, and pefabloc SC Entamoeba histolytica
3.4.22.35 tosylsulfonylleucylchloromethyl ketone i.e. TLCK Entamoeba histolytica
3.4.22.35 tosylsulfonylphenylalanylchloromethyl ketone i.e. TPCK Entamoeba histolytica
3.4.22.35 trans-epoxysuccinyl-L-leucylamido-(4-guanidino)butane
-
 Entamoeba histolytica

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.22.35 extracellular secretion Entamoeba histolytica
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.22.35 mucin MUC2 polymer + H2O Entamoeba histolytica enzyme is involved, together with other Entamoeba histolytica cysteine proteinases, in the degradation of mucin in the mucous layer of the colon epithelium, altering the protective function to facilitate parasite attachment ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.35 Entamoeba histolytica
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.35 benzyloxycarbonyl-Arg-Arg-4-nitroanilide + H2O
-
 Entamoeba histolytica benzyloxycarbonyl-Arg-Arg + 4-nitroaniline
-
 ?
3.4.22.35 mucin + H2O
-
 Entamoeba histolytica ?
-
 ?
3.4.22.35 mucin MUC2 polymer + H2O enzyme is involved, together with other Entamoeba histolytica cysteine proteinases, in the degradation of mucin in the mucous layer of the colon epithelium, altering the protective function to facilitate parasite attachment Entamoeba histolytica ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.22.35 Entamoeba histolytica cysteine proteinase
-
 Entamoeba histolytica

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.22.35 37
-
 assay at Entamoeba histolytica