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Literature summary extracted from

  • Rojkjaer, R.; Schmaier, A.H.
    Activation of the plasma kallikrein/kinin system on endothelial cell membranes (1999), Immunopharmacology, 43, 109-114.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.21.34 Factor XII essential for activation on artificial surfaces Homo sapiens
3.4.21.34 kininogen dependent on in vivo, high molecular weight, in complex with prekallikrein Homo sapiens
3.4.21.34 additional information prekallikrein activation mechanism, in vitro activated when expose to artificial negatively charged surfaces, in vivo activated as prekallikrein/kininogen complex by an antipain sensitive protease Homo sapiens
3.4.21.34 Zn2+ prekallikrein, required, optimal activation on cells at 0.008 mM, activation range 0.005-0.01 mM, higher concentration inhibit, regulatory role Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.34 2-mercaptoethanol inhibition of prekallikrein activation Homo sapiens
3.4.21.34 antipain inhibition of prekallikrein activation Homo sapiens
3.4.21.34 cysteine inhibition of prekallikrein activation Homo sapiens
3.4.21.34 dithiothreitol inhibition of prekallikrein activation Homo sapiens
3.4.21.34 glutathione inhibition of prekallikrein activation Homo sapiens
3.4.21.34 HgCl2 inhibition of prekallikrein activation Homo sapiens
3.4.21.34 Z-Phe-OH inhibition of prekallikrein activation Homo sapiens
3.4.21.34 Zn2+ inhibits the activation of prekallikrein at concentrations above 0.01 mM, regulatory role Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.21.34 membrane complexed with kininogen Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.34 kininogen + H2O Homo sapiens
-
 bradykinin + fragment of kininogen
-
 ir
3.4.21.34 additional information Homo sapiens involved in plasma and vascular fibrinolytic activity ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.34 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.34 endothelial cell surface, prekallikrein Homo sapiens
-
3.4.21.34 plasma
-
 Homo sapiens
-
3.4.21.34 platelet surface Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.34 factor XII + H2O activation of factor XII Homo sapiens ?
-
 ?
3.4.21.34 kininogen + H2O
-
 Homo sapiens bradykinin + fragment of kininogen
-
 ?
3.4.21.34 kininogen + H2O
-
 Homo sapiens bradykinin + fragment of kininogen
-
 ir
3.4.21.34 additional information involved in plasma and vascular fibrinolytic activity Homo sapiens ?
-
 ?
3.4.21.34 plasminogen + H2O activation of plasminogen Homo sapiens plasmin + ?
-
 ir
3.4.21.34 pro-urokinase + H2O activation of pro-urokinase Homo sapiens urokinase + ?
-
 ?