EC Number | Cloned (Comment) | Organism |
---|---|---|
6.4.1.3 | expressed in Escherichia coli | Homo sapiens |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
6.4.1.3 | A497V | significantly increased activity | Homo sapiens |
6.4.1.3 | A513_R514insP | insertion, severe degradation of the subunit | Homo sapiens |
6.4.1.3 | D178H | increased alpha/beta subunit ratio, very low activity | Homo sapiens |
6.4.1.3 | DELTA408 | catalytically inactive | Homo sapiens |
6.4.1.3 | DELTA499 | severe degradation of the subunit | Homo sapiens |
6.4.1.3 | DELTA514 | severe degradation of the subunit | Homo sapiens |
6.4.1.3 | E168K | increased alpha/beta subunit ratio, very low activity | Homo sapiens |
6.4.1.3 | G131R | catalytically inactive | Homo sapiens |
6.4.1.3 | G198D | catalytically inactive | Homo sapiens |
6.4.1.3 | L519P | complete degradation of the subunit | Homo sapiens |
6.4.1.3 | M442T | catalytically inactive | Homo sapiens |
6.4.1.3 | N536D | complete degradation of the subunit | Homo sapiens |
6.4.1.3 | P228L | increased alpha/beta subunit ratio, very low activity | Homo sapiens |
6.4.1.3 | R165W | increased alpha/beta subunit ratio, very low activity | Homo sapiens |
6.4.1.3 | R410W | very low activity | Homo sapiens |
6.4.1.3 | R44P | catalytically inactive | Homo sapiens |
6.4.1.3 | R512C | severe degradation of the subunit | Homo sapiens |
6.4.1.3 | S106R | catalytically inactive | Homo sapiens |
6.4.1.3 | V205D | catalytically inactive | Homo sapiens |
6.4.1.3 | V205D | increased alpha/beta subunit ratio | Homo sapiens |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
6.4.1.3 | mitochondrion | - |
Homo sapiens | 5739 | - |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
6.4.1.3 | Mg2+ | required to form a complex with ATP | Homo sapiens |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
6.4.1.3 | 800000 | - |
- |
Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
6.4.1.3 | ATP + propanoyl-CoA + HCO3- | Homo sapiens | key enzyme in catabolic pathways for odd-chain fatty acids, cholesterol and branched chain amino acids | ADP + phosphate + (S)-methylmalonyl-CoA | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
6.4.1.3 | Homo sapiens | - |
cDNA encoding for the alpha subunit | - |
6.4.1.3 | Homo sapiens | P05166 | cDNA encoding for the beta subunit | - |
EC Number | Purification (Comment) | Organism |
---|---|---|
6.4.1.3 | recombinant enzymes from Escherichia coli | Homo sapiens |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
6.4.1.3 | ATP + propanoyl-CoA + HCO3- | - |
Homo sapiens | ADP + phosphate + (S)-methylmalonyl-CoA | - |
? | |
6.4.1.3 | ATP + propanoyl-CoA + HCO3- | key enzyme in catabolic pathways for odd-chain fatty acids, cholesterol and branched chain amino acids | Homo sapiens | ADP + phosphate + (S)-methylmalonyl-CoA | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
6.4.1.3 | dodecamer | 6 alpha and 6 beta subunits | Homo sapiens |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
6.4.1.3 | biotin | bound to enzyme | Homo sapiens |