EC Number | Cloned (Comment) | Organism |
---|---|---|
3.1.2.22 | expression as glutathione S-transferase fusion protein in BHK and CHO cells, localization of the recombinant enzyme out side the lysosomes and endosomes | Mus musculus |
3.1.2.22 | expression of the enzyme in Caco-2 cells, orientation to the basolateral side, also after endocytosis of the recombinant enzyme into Caco-2 cells | Homo sapiens |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
3.1.2.22 | lysosome | enzyme is recognized by the mannose 6-phosphate receptor and routed to the lysosome | Homo sapiens | 5764 | - |
3.1.2.22 | additional information | not in lysosomes of mouse brain or neurons | Mus musculus | - |
- |
3.1.2.22 | synaptic vesicle | - |
Mus musculus | 8021 | - |
3.1.2.22 | synaptosome | - |
Mus musculus | - |
- |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
3.1.2.22 | 37000 | - |
x * 37000, SDS-PAGE | Mus musculus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.1.2.22 | additional information | Homo sapiens | enzyme deficiency causes progressive neurological disorder infantile neuronal ceroid lipofuscinosis, INCL | ? | - |
? | |
3.1.2.22 | additional information | Mus musculus | the enzyme has a role outside the lysosome in the brain and might be associated with synaptic functioning | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.1.2.22 | Homo sapiens | - |
- |
- |
3.1.2.22 | Mus musculus | - |
- |
- |
EC Number | Reaction | Comment | Organism | Reaction ID |
---|---|---|---|---|
3.1.2.22 | palmitoyl[protein] + H2O = palmitate + protein | specific for long-chain thioesters of fatty acids from S-acylated residues in proteins, palmitoyl cysteine and palmitoyl-CoA | Mus musculus | |
3.1.2.22 | palmitoyl[protein] + H2O = palmitate + protein | specific for long-chain thioesters of fatty acids from S-acylated residues in proteins, palmitoyl cysteine and palmitoyl-CoA | Homo sapiens |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.1.2.22 | brain | - |
Mus musculus | - |
3.1.2.22 | brain | - |
Homo sapiens | - |
3.1.2.22 | Caco-2 cell | exclusively localized to the basolateral side of the polarized cells | Homo sapiens | - |
3.1.2.22 | epithelium | - |
Homo sapiens | - |
3.1.2.22 | neuron | - |
Mus musculus | - |
3.1.2.22 | neuron | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.1.2.22 | additional information | enzyme deficiency causes progressive neurological disorder infantile neuronal ceroid lipofuscinosis, INCL | Homo sapiens | ? | - |
? | |
3.1.2.22 | additional information | the enzyme has a role outside the lysosome in the brain and might be associated with synaptic functioning | Mus musculus | ? | - |
? | |
3.1.2.22 | palmitoyl-[protein] + H2O | - |
Mus musculus | palmitate + protein | - |
? | |
3.1.2.22 | palmitoyl-[protein] + H2O | - |
Homo sapiens | palmitate + protein | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
3.1.2.22 | ? | x * 37000, SDS-PAGE | Mus musculus |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.1.2.22 | palmitoyl protein thioesterase | - |
Mus musculus |
3.1.2.22 | palmitoyl protein thioesterase | - |
Homo sapiens |
3.1.2.22 | PPT | - |
Mus musculus |
3.1.2.22 | PPT | - |
Homo sapiens |