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Literature summary extracted from

  • Herman, C.; Thevenet, D.; Bouloc, P.; Walker, G.C.; D'Ari, R.
    Degradation of carboxy-terminal-tagged cytoplasmic proteins by the Escherichia coli protease HflB (FtsH) (1998), Genes Dev., 12, 1348-1355.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.24.B17 expression of wild-type and mutant from plasmid Escherichia coli

Protein Variants

EC Number Protein Variants Comment Organism
3.4.24.B17 additional information enzyme mutant still shows activity with substrates derivative of the N-terminal domain of the lambdacI repressor tagged with cI105 and SsrA Escherichia coli

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.24.B17 membrane integral, with the active site in the cytoplasm Escherichia coli 16020
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.24.B17 Zn2+ zinc protease Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.B17 protein + H2O Escherichia coli tail specific pathway for removing abnormal cytoplasmic proteins via the enzyme, disposition by degradation of polypeptides synthesized from truncated mRNA molecules and are C-terminally tagged with an 11-amino-acid nonpolar destabilizing tail via a mechanism involving the 10Sa stable RNA peptides
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.B17 Escherichia coli P0AAI3 K12 derivatives, strain JM105
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.B17 additional information enzyme shows overlapping substrate specificity with the proteases C1pXP and C1pAP, the enzymes can compensate for each other in degrading the c1-SsrA tagged substrate protein Escherichia coli ?
-
 ?
3.4.24.B17 protein + H2O
-
 Escherichia coli peptides
-
 ?
3.4.24.B17 protein + H2O tail specific pathway for removing abnormal cytoplasmic proteins via the enzyme, disposition by degradation of polypeptides synthesized from truncated mRNA molecules and are C-terminally tagged with an 11-amino-acid nonpolar destabilizing tail via a mechanism involving the 10Sa stable RNA Escherichia coli peptides
-
 ?
3.4.24.B17 protein lambdaCII + H2O regulatory protein Escherichia coli ?
-
 ?
3.4.24.B17 protein lambdaCIII + H2O regulatory protein Escherichia coli ?
-
 ?
3.4.24.B17 protein sigma32 + H2O heat shock factor Escherichia coli ?
-
 ?
3.4.24.B17 unstable derivatives of the N-terminal domain of the lambdacI repressor + H2O 3 derivatives with a nonpolar pentapeptide tail, i.e. cI104, cI105, cI108, and 1 with the SsrAtag, i.e. cI-SsrA Escherichia coli ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.B17 cell division protein ftsH
-
 Escherichia coli
3.4.24.B17 FtsH
-
 Escherichia coli
3.4.24.B17 FTSH_ECOLI
-
 Escherichia coli
3.4.24.B17 HflB
-
 Escherichia coli
3.4.24.B17 M41.001 Merops-ID Escherichia coli

Cofactor

EC Number Cofactor Comment Organism Structure
3.4.24.B17 ATP dependent on Escherichia coli