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Literature summary extracted from

  • Sanchez, L.B.; Morrison, H.G.; Sogin, M.L.; Muller, M.
    Cloning and sequencing of an acetyl-CoA synthetase (ADP-forming) gene from the amitochondriate protist, Giardia lamblia (1999), Gene, 233, 225-231.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
6.2.1.13 expression in Escherichia coli Giardia intestinalis

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
6.2.1.13 0.06
-
 acetyl-CoA
-
 Giardia intestinalis
6.2.1.13 0.2
-
 ADP
-
 Giardia intestinalis
6.2.1.13 1.35
-
 phosphate
-
 Giardia intestinalis

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
6.2.1.13 78000
-
 estimation from sequence of cDNA Giardia intestinalis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.2.1.13 ADP + phosphate + acetyl-CoA Giardia intestinalis enzyme catalyzes acetate formation and ATP generation during fermentation of pyruvate to acetate ATP + acetate + CoA
-
 ?
6.2.1.13 ADP + phosphate + acetyl-CoA Giardia intestinalis WB / CC 30957 enzyme catalyzes acetate formation and ATP generation during fermentation of pyruvate to acetate ATP + acetate + CoA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.2.1.13 Giardia intestinalis Q9Y1N2 clone 6
-
6.2.1.13 Giardia intestinalis WB / CC 30957 Q9Y1N2 clone 6
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.2.1.13 ADP + phosphate + acetyl-CoA
-
 Giardia intestinalis ATP + acetate + CoA
-
 ?
6.2.1.13 ADP + phosphate + acetyl-CoA enzyme catalyzes acetate formation and ATP generation during fermentation of pyruvate to acetate Giardia intestinalis ATP + acetate + CoA
-
 ?
6.2.1.13 ADP + phosphate + acetyl-CoA
-
 Giardia intestinalis WB / CC 30957 ATP + acetate + CoA
-
 ?
6.2.1.13 ADP + phosphate + acetyl-CoA enzyme catalyzes acetate formation and ATP generation during fermentation of pyruvate to acetate Giardia intestinalis WB / CC 30957 ATP + acetate + CoA
-
 ?
6.2.1.13 ADP + phosphate + butanoyl-CoA less efficiently than acetyl-CoA Giardia intestinalis ATP + butanoate + CoA
-
 ?
6.2.1.13 ADP + phosphate + butanoyl-CoA less efficiently than acetyl-CoA Giardia intestinalis WB / CC 30957 ATP + butanoate + CoA
-
 ?

Subunits

EC Number Subunits Comment Organism
6.2.1.13 monomer
-
 Giardia intestinalis

pI Value

EC Number Organism Comment pI Value Maximum pI Value
6.2.1.13 Giardia intestinalis estimation from sequence of cDNA
-
 8.2