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Literature summary extracted from

  • Carriere, F.; Renou, C.; Lopez, V.; De Caro, J.; Ferrato, F.; Lengsfeld, H.; De Caro, A.; Laugier, R.; Verger, R.
    The specific activities of human digestive lipases measured from the in vivo and in vitro lipolysis of test meals (2000), Gastroenterology, 119, 949-960.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.1.3 bile salt pancreatic lipase, stimulation Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.1.3 10000
-
 colipase Homo sapiens
3.1.1.3 50000
-
 HPL Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.1.3 additional information Homo sapiens measurement of in vivo enzyme activities by use of a liquid lipid containing test meal, determination of free fatty acids ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.3 Homo sapiens
-
 digestive lipases HPL and HGL, healthy male and female humans
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.3 gastrointestinal tract gastric lipase HGL Homo sapiens
-
3.1.1.3 pancreas pancreatic lipase HPL, secretion from fundic mucosa Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.1.1.3 15
-
 purified pancreatic lipase, solid meal Homo sapiens
3.1.1.3 32
-
 purified gastric lipase, liquid test meal Homo sapiens
3.1.1.3 34
-
 purified gastric lipase, solid test meal Homo sapiens
3.1.1.3 43
-
 purified pancreatic lipase, liquid meal Homo sapiens
3.1.1.3 1300
-
 purified gastric lipase, substrate tributyrin Homo sapiens
3.1.1.3 8000
-
 purified pancreaic lipase, substrate tributyrin Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.3 additional information measurement of in vivo enzyme activities by use of a liquid lipid containing test meal, determination of free fatty acids Homo sapiens ?
-
 ?
3.1.1.3 tributyrin + H2O nonphysiologic substrate Homo sapiens dibutyrin + butyrate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.3 HGL
-
 Homo sapiens
3.1.1.3 HPL
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.1.3 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.1.3 4.5
-
 gastric lipase HGL, assay at Homo sapiens
3.1.1.3 6.5 7.5 pancreatic lipase HPL Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
3.1.1.3 Colipase specific cofactor of pancreatic lipase Homo sapiens