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Literature summary extracted from

  • Yenush, L.; Belles, J.M.; Lopez-Coronado, J.M.; Gil-Mascarell, R.; Serrano, R.; Rodriguez, P.L.
    A novel target of lithium therapy (2000), FEBS Lett., 467, 321-325.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.1.3.7 medicine enzyme as a potential target of lithium therapy Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.3.7 cloning of HsPIP and expression in Escherichia coli Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.3.7 Li+
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.3.7 0.0004
-
 inositol-1,4-bisphosphate pH 7.5, 30°C Homo sapiens
3.1.3.7 0.001
-
 adenosine 3',5'-bisphosphate pH 7.5, 30°C Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.3.7 Mg2+ required, optimal concentration of 1 mM Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.3.7 33000
-
 SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.3.7 adenosine 3',5'-bisphosphate + H2O Homo sapiens the activity of enzyme is required while 3'-phosphoadenosine 5'-phosphate is a potent inhibitor of a variety of enzymes that use 3'-phosphoadenosine 5'-phosphate as cosubstrate adenosine 5'-phosphate + phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.7 Homo sapiens O95861
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.3.7 recombinant enzyme Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.7 adenosine 2',5'-bisphosphate + H2O
-
 Homo sapiens adenosine 5'-phosphate + phosphate
-
 ?
3.1.3.7 adenosine 3',5'-bisphosphate + H2O
-
 Homo sapiens adenosine 5'-phosphate + phosphate
-
 ?
3.1.3.7 adenosine 3',5'-bisphosphate + H2O the activity of enzyme is required while 3'-phosphoadenosine 5'-phosphate is a potent inhibitor of a variety of enzymes that use 3'-phosphoadenosine 5'-phosphate as cosubstrate Homo sapiens adenosine 5'-phosphate + phosphate
-
 ?
3.1.3.7 inositol-1,4-bisphosphate + H2O
-
 Homo sapiens inositol 4-phosphate + phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.3.7 3'(2')-phosphoadenosine 5’-phosphate phosphatase
-
 Homo sapiens
3.1.3.7 PAP-phosphatease
-
 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.1.3.7 0.3
-
 Li+ pH 7.5, 30°C, substrate: adenosine 3’,5’-bisphosphate Homo sapiens
3.1.3.7 0.6
-
 Li+ pH 7.5, 30°C, substrate: inositol-1,4-bisphosphate Homo sapiens