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Literature summary extracted from

  • Arteaga-Nieto, P.; Lopez-Romero, E.; Teran-Figueroa, Y.; Cano-Canchola, C.; Luna Arias, J.P.; Flores-Carreon, A.; Calvo-Mendez, C.
    Entamoeba histolytica: purification and characterization of ornithine decarboxylase (2002), Exp. Parasitol., 101, 215-222.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.1.1.17 1,3-diaminopropane 10 mM, approx. 60% inhibition Entamoeba histolytica
4.1.1.17 1,4-Diamino-2-butanone 5 mM, complete inhibition Entamoeba histolytica
4.1.1.17 additional information not inhibited by alpha-difluoromethylornithine Entamoeba histolytica

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
4.1.1.17 45000
-
 5 * 45000, SDS-PAGE Entamoeba histolytica
4.1.1.17 216000
-
 gel filtration Entamoeba histolytica

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.1.1.17 L-ornithine Entamoeba histolytica involved in polyamine biosynthesis putrescine + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.17 Entamoeba histolytica
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.1.1.17 ammonium sulfate, DEAE Bio-Gel, Bio-Gel, Affi-Gel 501 Entamoeba histolytica

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
4.1.1.17 24.8
-
-
 Entamoeba histolytica

Storage Stability

EC Number Storage Stability Organism
4.1.1.17 -70°C, 2 years, no loss of activity Entamoeba histolytica
4.1.1.17 4°C, 1 month, no loss of activity Entamoeba histolytica

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.17 L-ornithine
-
 Entamoeba histolytica putrescine + CO2
-
 ?
4.1.1.17 L-ornithine involved in polyamine biosynthesis Entamoeba histolytica putrescine + CO2
-
 ?

Subunits

EC Number Subunits Comment Organism
4.1.1.17 pentamer 5 * 45000, SDS-PAGE Entamoeba histolytica

Synonyms

EC Number Synonyms Comment Organism
4.1.1.17 ODC
-
 Entamoeba histolytica

Cofactor

EC Number Cofactor Comment Organism Structure
4.1.1.17 pyridoxal 5'-phosphate absolutely required for activity Entamoeba histolytica