EC Number | Application | Comment | Organism |
---|---|---|---|
3.4.13.9 | medicine | enzyme is a possible target for doxycyclin-induced inhibition of collagen synthesis in the treatment of osteoarthritis | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.4.13.9 | doxycyclin | induces down-regulation of the enzyme as a post-translational event | Homo sapiens |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
3.4.13.9 | cytosol | - |
Homo sapiens | 5829 | - |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
3.4.13.9 | Mn2+ | dependent on | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.13.9 | additional information | Homo sapiens | the enzyme is involved in collagen metabolism, enzyme activity is regulated through the beta1 integrin receptor | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.13.9 | Homo sapiens | - |
- |
- |
EC Number | Reaction | Comment | Organism | Reaction ID |
---|---|---|---|---|
3.4.13.9 | hydrolysis of Xaa-/-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro | cleaves imidodipeptides containing C-terminal proline providing a large amount of proline for collagen resynthesis | Homo sapiens |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.4.13.9 | chondrocyte | - |
Homo sapiens | - |
3.4.13.9 | skin fibroblast | cell culture | Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.13.9 | Gly-Pro + H2O | - |
Homo sapiens | Gly + Pro | - |
? | |
3.4.13.9 | additional information | the enzyme is involved in collagen metabolism, enzyme activity is regulated through the beta1 integrin receptor | Homo sapiens | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.4.13.9 | More | enzyme belongs to the methionyl amino peptidase family M24, fomerly EC 3.4.3.7 | Homo sapiens |
3.4.13.9 | prolidase | exopeptidase | Homo sapiens |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
3.4.13.9 | 37 | - |
assay at | Homo sapiens |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
3.4.13.9 | 7.8 | - |
assay at | Homo sapiens |