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Literature summary extracted from

  • Karna, E.; Palka, J.; Wolczynski, S.
    Doxycycline-induced inhibition of prolidase activity in human skin fibroblasts and its involvement in impaired collagen biosynthesis (2001), Eur. J. Pharmacol., 430, 25-31.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.4.13.9 medicine enzyme is a possible target for doxycyclin-induced inhibition of collagen synthesis in the treatment of osteoarthritis Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.13.9 doxycyclin induces down-regulation of the enzyme as a post-translational event Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.13.9 cytosol
-
Homo sapiens 5829
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.13.9 Mn2+ dependent on Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.13.9 additional information Homo sapiens the enzyme is involved in collagen metabolism, enzyme activity is regulated through the beta1 integrin receptor ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.4.13.9 Homo sapiens
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
3.4.13.9 hydrolysis of Xaa-/-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro cleaves imidodipeptides containing C-terminal proline providing a large amount of proline for collagen resynthesis Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.13.9 chondrocyte
-
Homo sapiens
-
3.4.13.9 skin fibroblast cell culture Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.13.9 Gly-Pro + H2O
-
Homo sapiens Gly + Pro
-
?
3.4.13.9 additional information the enzyme is involved in collagen metabolism, enzyme activity is regulated through the beta1 integrin receptor Homo sapiens ?
-
?

Synonyms

EC Number Synonyms Comment Organism
3.4.13.9 More enzyme belongs to the methionyl amino peptidase family M24, fomerly EC 3.4.3.7 Homo sapiens
3.4.13.9 prolidase exopeptidase Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.13.9 37
-
assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.13.9 7.8
-
assay at Homo sapiens