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Literature summary extracted from

  • Sanghani, S.P.; Davis, W.I.; Dumaual, N.G.; Mahrenholz, A.; Bosron, W.F.
    Identification of microsomal rat liver carboxylesterases and their activity with retinyl palmitate (2002), Eur. J. Biochem., 269, 4387-4398.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.1.1 DNA sequence determination and analysis Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.1.1 0.00089
-
retinyl palmitate isozyme ES3, pH 8.0, 37°C Rattus norvegicus
3.1.1.1 0.0012
-
retinyl palmitate isozyme ES10, pH 8.0, 37°C Rattus norvegicus
3.1.1.1 0.0014
-
retinyl palmitate isozyme ES4, pH 8.0, 37°C Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.1.1 microsome
-
Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.1.1 additional information Rattus norvegicus phylogenetic tree for rat liver carboxylesterases ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.1 Rattus norvegicus O35535 male Sprague-Dawley rat, isoenzyme termed D50580 or CE21p, belonging to the nonspecific carboxylesterase family
-
3.1.1.1 Rattus norvegicus O70631 male Sprague-Dawley rat, isoenzyme termed AB010635, belonging to the nonspecific carboxylesterase CES2 family
-
3.1.1.1 Rattus norvegicus P16303 male Sprague-Dawley rat, isoenzyme ES10, belonging to the nonspecific carboxylesterase family
-
3.1.1.1 Rattus norvegicus Q63108 male Sprague-Dawley rat, isoenzyme ES3, belonging to the nonspecific carboxylesterase family
-
3.1.1.1 Rattus norvegicus Q64573 male Sprague-Dawley rat, isoenzyme ES4, belonging to the nonspecific carboxylesterase family
-
3.1.1.1 Rattus norvegicus Q8K3R0 male Sprague-Dawley rat, isoenzyme termed AY034877, belonging to the nonspecific carboxylesterase CES2 family
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.1.1.1 glycoprotein N-glycosylated residue is Asn275 Rattus norvegicus
3.1.1.1 glycoprotein N-glycosylated residue is Asn79 Rattus norvegicus
3.1.1.1 glycoprotein N-glycosylated residues are Asn261, Asn272, and Asn550 Rattus norvegicus
3.1.1.1 glycoprotein N-glycosylated residues are Asn79 and Asn489 Rattus norvegicus
3.1.1.1 glycoprotein N-glycosylated residues are Asn79, Asn107, and Asn489 Rattus norvegicus
3.1.1.1 no glycoprotein
-
Rattus norvegicus

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.1.1 isozyme AB010635 from liver microsomes Rattus norvegicus
3.1.1.1 isozyme AY034877 from liver microsomes Rattus norvegicus
3.1.1.1 isozyme D50580 from liver microsomes Rattus norvegicus
3.1.1.1 isozyme ES10 from liver microsomes Rattus norvegicus
3.1.1.1 isozyme ES3 from liver microsomes Rattus norvegicus
3.1.1.1 isozyme ES4 from liver microsomes Rattus norvegicus

Reaction

EC Number Reaction Comment Organism Reaction ID
3.1.1.1 a carboxylic ester + H2O = an alcohol + a carboxylate a catalytic triad is formed by residues Ser221, Glu353, and His466 Rattus norvegicus
3.1.1.1 a carboxylic ester + H2O = an alcohol + a carboxylate a catalytic triad is formed by residues Ser224, Glu341, and His452 Rattus norvegicus
3.1.1.1 a carboxylic ester + H2O = an alcohol + a carboxylate a catalytic triad is formed by residues Ser227, Glu344, and His456 Rattus norvegicus
3.1.1.1 a carboxylic ester + H2O = an alcohol + a carboxylate a catalytic triad is formed by residues Ser230, Glu347, and His459 Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.1 kidney
-
Rattus norvegicus
-
3.1.1.1 liver
-
Rattus norvegicus
-
3.1.1.1 lung
-
Rattus norvegicus
-
3.1.1.1 additional information no isozyme expression in brain, thymus, heart, and spleen Rattus norvegicus
-
3.1.1.1 skin
-
Rattus norvegicus
-
3.1.1.1 small intestine
-
Rattus norvegicus
-
3.1.1.1 stomach
-
Rattus norvegicus
-
3.1.1.1 testis
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.1.1.1 16.7
-
purified isozyme ES4, substrate 4-methylumbelliferyl acetate Rattus norvegicus
3.1.1.1 29.7
-
purified isozyme D50580, substrate 4-methylumbelliferyl acetate Rattus norvegicus
3.1.1.1 30.1
-
purified isozyme ES3, substrate 4-methylumbelliferyl acetate Rattus norvegicus
3.1.1.1 41.9
-
purified isozyme ES10, substrate 4-methylumbelliferyl acetate Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.1 4-methylumbelliferyl acetate + H2O
-
Rattus norvegicus 4-methylumbelliferone + acetate
-
?
3.1.1.1 additional information phylogenetic tree for rat liver carboxylesterases Rattus norvegicus ?
-
?
3.1.1.1 retinyl palmitate + H2O
-
Rattus norvegicus retinol + palmitate
-
?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.1 CE21p
-
Rattus norvegicus
3.1.1.1 CES2
-
Rattus norvegicus
3.1.1.1 ES10
-
Rattus norvegicus
3.1.1.1 ES3
-
Rattus norvegicus
3.1.1.1 ES4
-
Rattus norvegicus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.1.1 37
-
assay at Rattus norvegicus

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
3.1.1.1 0.00083
-
retinyl palmitate isozyme AB010635, pH 8.0, 37°C Rattus norvegicus
3.1.1.1 0.0028 0.0045 retinyl palmitate isozyme D50580, pH 8.0, 37°C Rattus norvegicus
3.1.1.1 0.0032
-
retinyl palmitate isozyme ES3, pH 8.0, 37°C Rattus norvegicus
3.1.1.1 0.004
-
retinyl palmitate isozyme ES10, pH 8.0, 37°C Rattus norvegicus
3.1.1.1 0.0075
-
retinyl palmitate isozyme ES4, pH 8.0, 37°C Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.1.1 7.3
-
assay at, substrate 4-methylumbelliferyl acetate Rattus norvegicus
3.1.1.1 8
-
assay at, substrate retinyl palmitate Rattus norvegicus

pI Value

EC Number Organism Comment pI Value Maximum pI Value
3.1.1.1 Rattus norvegicus isozyme AB010635, isoelectric focusing
-
4.8
3.1.1.1 Rattus norvegicus isozyme D50580, isoelectric focusing
-
5.3
3.1.1.1 Rattus norvegicus isozyme ES3, isoelectric focusing
-
5.7
3.1.1.1 Rattus norvegicus isozyme AY034877, isoelectric focusing
-
6
3.1.1.1 Rattus norvegicus isozyme ES10, isoelectric focusing
-
6.1
3.1.1.1 Rattus norvegicus isozyme ES4, isoelectric focusing
-
6.7