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Literature summary extracted from

  • Tang, X.; Waksman, M.; Ely, Y.; Liscovitch, M.
    Characterization and regulation of yeast Ca2+-dependent phosphatidylethanolamine-phospholipase D activity (2002), Eur. J. Biochem., 269, 3821-3830.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.4.4 Ca2+ required, 1 mM Saccharomyces cerevisiae
3.1.4.4 H2O2 exposure of cells to H2O2 leads to transient increase in activity followed by 90% decrease Saccharomyces cerevisiae

Protein Variants

EC Number Protein Variants Comment Organism
3.1.4.4 additional information sec14 mutant, enzyme activity is elevated by 40% at restrictive temperature Saccharomyces cerevisiae

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.4 Ba2+ 1 mM, 15-25% inhibition Saccharomyces cerevisiae
3.1.4.4 Co2+ 1 mM, 50-60% inhibition Saccharomyces cerevisiae
3.1.4.4 H2O2 exposure of cells to H2O2 leads to transient increase in activity followed by 90% decrease Saccharomyces cerevisiae
3.1.4.4 Inositol at 0.075 mM in culture medium,reduction of enzyme activity by 30-40% Saccharomyces cerevisiae
3.1.4.4 Mn2+ 1 mM, 45-55% inhibition Saccharomyces cerevisiae
3.1.4.4 Zn2+ 1 mM, 45% inhibition Saccharomyces cerevisiae

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.4.4 cytosol
-
 Saccharomyces cerevisiae 5829
-
3.1.4.4 membrane associated to Saccharomyces cerevisiae 16020
-

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.4 Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.4 additional information does not catalyze transphosphatidylation reaction with primary short-chain alcohols Saccharomyces cerevisiae ?
-
 ?
3.1.4.4 phosphatidylethanolamine + H2O
-
 Saccharomyces cerevisiae ethanolamine + phosphatidate
-
 ?
3.1.4.4 phosphatidylserine + H2O
-
 Saccharomyces cerevisiae L-serine + phosphatidate
-
 ?