EC Number | Cloned (Comment) | Organism |
---|---|---|
3.4.11.3 | leucine aminopeptidase/oxytocinase, expression in Chinese hamster ovary cells | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.4.11.3 | 1,10-phenanthroline | 0.1 mM, 83% inhibition. 0.01 mM, 10% inhibition | Homo sapiens | |
3.4.11.3 | amastatin | 0.1 mM, 96% inhibition. 0.01 mM, 79% inhibition | Homo sapiens | |
3.4.11.3 | bestatin | 0.1 mM, 43% inhibition. 0.01 mM, 12% inhibition | Homo sapiens | |
3.4.11.3 | CuCl2 | 0.1 mM, 91% inhibition. 0.01 mM, 87% inhibition | Homo sapiens | |
3.4.11.3 | leupeptin | 0.1 mM, 53% inhibition | Homo sapiens | |
3.4.11.3 | additional information | EDTA has no effect | Homo sapiens | |
3.4.11.3 | pepstatin A | 0.1 mM, 70% inhibition | Homo sapiens | |
3.4.11.3 | puromycin | 0.1 mM, 36% inhibition. 0.01 mM, 5% inhibition | Homo sapiens | |
3.4.11.3 | ZnCl2 | 0.1 mM, 98% inhibition. 0.01 mM, 77% inhibition | Homo sapiens |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.4.11.3 | 0.0225 | - |
Leu-4-methylcoumaryl-7-amide | pH 7.5, 37°C | Homo sapiens | |
3.4.11.3 | 0.0436 | - |
S-benzyl-Cys-4-methylcoumaryl-7-amide | pH 7.5, 37°C | Homo sapiens |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
3.4.11.3 | membrane | bound to | Homo sapiens | 16020 | - |
3.4.11.3 | soluble | recombinant enzyme expressed in Chinese hamster ovary cells | Homo sapiens | - |
- |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
3.4.11.3 | Zinc | enzyme contains 1 mol of zinc per mol of enzyme, contains the consensus HEXXH(X)18E motif of zinc-metallopeptidase proteins | Homo sapiens |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
3.4.11.3 | 170000 | - |
2 * 170000, SDS-PAGE | Homo sapiens |
3.4.11.3 | 280000 | - |
sedimentation velocity experiments | Homo sapiens |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.11.3 | Homo sapiens | - |
- |
- |
EC Number | Posttranslational Modification | Comment | Organism |
---|---|---|---|
3.4.11.3 | glycoprotein | - |
Homo sapiens |
EC Number | Purification (Comment) | Organism |
---|---|---|
3.4.11.3 | - |
Homo sapiens |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.4.11.3 | placenta | - |
Homo sapiens | - |
3.4.11.3 | serum | serum level of the enzyme increases with gestation | Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.11.3 | Arg-4-methylcoumaryl-7-amide + H2O | - |
Homo sapiens | Arg + 7-amino-4-methylcoumarin | - |
? | |
3.4.11.3 | Leu-4-methylcoumaryl-7-amide + H2O | - |
Homo sapiens | Leu + 7-amino-4-methylcoumarin | - |
? | |
3.4.11.3 | Lys-4-methylcoumaryl-7-amide + H2O | - |
Homo sapiens | Lys + 7-amino-4-methylcoumarin | - |
? | |
3.4.11.3 | Met-4-methylcoumaryl-7-amide + H2O | - |
Homo sapiens | Met + 7-amino-4-methylcoumarin | - |
? | |
3.4.11.3 | S-benzyl-Cys-4-methylcoumaryl-7-amide + H2O | - |
Homo sapiens | S-benzyl-Cys + 7-amino-4-methylcoumarin | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
3.4.11.3 | dimer | 2 * 170000, SDS-PAGE | Homo sapiens |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.4.11.3 | leucine aminopeptidase/oxytocinase | - |
Homo sapiens |
3.4.11.3 | P-LAP | - |
Homo sapiens |
EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.4.11.3 | 0.04 | 1.97 | Leu-4-methylcoumaryl-7-amide | pH 7.5, 37°C | Homo sapiens | |
3.4.11.3 | 9.18 | - |
Leu-4-methylcoumaryl-7-amide | pH 7.5, 37°C | Homo sapiens | |
3.4.11.3 | 12.4 | - |
S-benzyl-Cys-4-methylcoumaryl-7-amide | pH 7.5, 37°C | Homo sapiens |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.4.11.3 | 0.0014 | - |
amastatin | pH 7.5, 37°C | Homo sapiens |