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Literature summary extracted from

  • Butler, G.S.; Will, H.; Atkinson, S.J.; Murphy, G.
    Membrane-type-2 matrix metalloproteinase can initiate the processing of progelatinase A and is regulated by the tissue inhibitors of metalloproteinases (1997), Eur. J. Biochem., 244, 653-657.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.24.B5 expression of the enzymes catalytic domain in Escherichia coli Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.B5 additional information no inhibition by tissue matrix metalloproteinase inhibitor TIMP-1 Homo sapiens
3.4.24.B5 tissue matrix metalloproteinase inhibitor TIMP-2
-
 Homo sapiens
3.4.24.B5 tissue matrix metalloproteinase inhibitor TIMP-3
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.24.B5 membrane on the cell surface Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.B5 matrix metalloproteinase progelatinase A + H2O Homo sapiens substrate is activated by cleavage matrix metalloproteinase gelatinase A
-
 ?
3.4.24.B5 protein + H2O Homo sapiens
-
 peptides
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.B5 Homo sapiens
-
 membrane-type-2 matrix metalloprotease
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.4.24.B5 additional information
-
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.B5 (7-methoxycoumarin-4-yl)acetyl-Pro-Leu-Gly-Leu-[3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl]-Ala-Arg-NH2 + H2O synthetic fluorogenic substrate Homo sapiens ?
-
 ?
3.4.24.B5 matrix metalloproteinase progelatinase A + H2O substrate is activated by cleavage Homo sapiens matrix metalloproteinase gelatinase A
-
 ?
3.4.24.B5 progelatinase A + H2O substrate is activated by cleavage Homo sapiens gelatinase A + ?
-
 ?
3.4.24.B5 protein + H2O
-
 Homo sapiens peptides
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.B5 M10.015 Merops-ID Homo sapiens
3.4.24.B5 membrane-type-2 matrix metalloproteinase
-
 Homo sapiens
3.4.24.B5 MT2 MMP
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.24.B5 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.24.B5 7.5
-
 assay at Homo sapiens