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Literature summary extracted from

  • Feinberg, H.; Uitdehaag, J.C.M.; Davies, J.M.; Wallis, R.; Drickamer, K.; Weis, W.I.
    Crystal structure of the CUB1-EGF-CUB2 region of mannose-binding protein associated serine protease-2 (2003), EMBO J., 22, 2348-2359.
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
3.4.21.104 hanging drop vapor diffusion method in the presence of Ca2+ Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.B7 additional information Rattus norvegicus involved in activation of complement cascade, circulates as a complex with mannose-binding protein, minimal functional unit for complement activation is a MASP homodimer bound to two mannose-binding protein trimeric subunits ?
-
 ?
3.4.21.B7 Protein + H2O Rattus norvegicus
-
 ?
-
 ?
3.4.21.104 Protein + H2O Rattus norvegicus enzyme circulates as a complex with mannose-binding protein, minimal functional unit for complement activation is a ASP homodimer bound to two mannose-binding protein trimeric subunits, complex is formed more readily in the presence of Ca2+ ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.B7 Rattus norvegicus
-
-
-
3.4.21.104 Rattus norvegicus Q9JJS8
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.21.104 proteolytic modification zymogen is cleaved into the catalytically active protease Rattus norvegicus

Reaction

EC Number Reaction Comment Organism Reaction ID
3.4.21.104 Selective cleavage after Arg223 in complement component C2 (-Ser-Leu-Gly-Arg-/-Lys-Ile-Gln-Ile) and after Arg76 in complement component C4 (-Gly-Leu-Gln-Arg-/-Ala-Leu-Glu-Ile) mechanism Rattus norvegicus
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.B7 additional information involved in activation of complement cascade, circulates as a complex with mannose-binding protein, minimal functional unit for complement activation is a MASP homodimer bound to two mannose-binding protein trimeric subunits Rattus norvegicus ?
-
 ?
3.4.21.B7 Protein + H2O
-
 Rattus norvegicus ?
-
 ?
3.4.21.104 Protein + H2O
-
 Rattus norvegicus ?
-
 ?
3.4.21.104 Protein + H2O enzyme circulates as a complex with mannose-binding protein, minimal functional unit for complement activation is a ASP homodimer bound to two mannose-binding protein trimeric subunits, complex is formed more readily in the presence of Ca2+ Rattus norvegicus ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.4.21.104 dimer crystallographic experiments Rattus norvegicus

Synonyms

EC Number Synonyms Comment Organism
3.4.21.B7 MASP-1
-
 Rattus norvegicus
3.4.21.104 MASP-2
-
 Rattus norvegicus