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Literature summary extracted from

  • Yaremchuk, A.; Cusack, S.; Tukalo, M.
    Crystal structure of a eukaryote/archaeon-like protyl-tRNA synthetase and its complex with tRNAPro(CGG) (2000), EMBO J., 19, 4745-4758.
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
6.1.1.15 X-ray diffraction structure determination at 2.43-2.85 A of crystals formed by the free enzyme or the enzyme complexed with tRNAPro Thermus thermophilus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
6.1.1.15 Zn2+ enzyme contains a unique additional zinc-binding domain Thermus thermophilus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.1.1.15 ATP + L-proline + tRNAPro Thermus thermophilus
-
 AMP + diphosphate + L-prolyl-tRNAPro
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.1.1.15 Thermus thermophilus
-
 class IIa synthetase of the eukaryote/archaeon-like structure type
-

Reaction

EC Number Reaction Comment Organism Reaction ID
6.1.1.15 ATP + L-proline + tRNAPro = AMP + diphosphate + L-prolyl-tRNAPro the C-terminal extremity folds back into the active site Thermus thermophilus
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.1.1.15 ATP + L-proline + tRNAPro
-
 Thermus thermophilus AMP + diphosphate + L-prolyl-tRNAPro
-
 ?
6.1.1.15 ATP + L-proline + tRNAPro initial docking state of the tRNAPro in which the anticodon stem-loop is engaged, particularly via the tRNAPro-specific bases G35 and G36, but the 3'-end does not enter the active site Thermus thermophilus AMP + diphosphate + L-prolyl-tRNAPro
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.1.1.15 Global RNA synthesis factor
-
 Thermus thermophilus
6.1.1.15 Pro-tRNA synthetase
-
 Thermus thermophilus
6.1.1.15 Proline translase
-
 Thermus thermophilus
6.1.1.15 Proline--tRNA ligase
-
 Thermus thermophilus
6.1.1.15 Prolyl RNA synthetase
-
 Thermus thermophilus
6.1.1.15 Prolyl-transfer ribonucleate synthetase
-
 Thermus thermophilus
6.1.1.15 Prolyl-transfer ribonucleic acid synthetase
-
 Thermus thermophilus
6.1.1.15 Prolyl-transfer RNA synthetase
-
 Thermus thermophilus
6.1.1.15 Prolyl-tRNA synthetase
-
 Thermus thermophilus
6.1.1.15 ProRS
-
 Thermus thermophilus
6.1.1.15 ProRSTT
-
 Thermus thermophilus

Cofactor

EC Number Cofactor Comment Organism Structure
6.1.1.15 ATP
-
 Thermus thermophilus