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Literature summary extracted from

  • Raushel, F.M.; Thoden, J.B.; Reinhart, G.D.; Holden, H.M.
    Carbamoyl phosphate synthetase: a crooked path from substrates to products (1998), Curr. Opin. Chem. Biol., 2, 624-632.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
6.3.5.5 ornithine
-
 Escherichia coli

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
6.3.5.5 the three active sites within the alpha,beta heterodimer are separated by a linear distance of nearly 100 A and are interconnected by two molecular tunnels Escherichia coli

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.3.5.5 IMP binds with good affinity to the enzyme, small effect below 35°C Escherichia coli
6.3.5.5 UMP
-
 Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.3.5.5 2 ATP + L-Gln + HCO3- Escherichia coli the product carbamoyl phosphate plays a critical role in both arginine and pyrimidine biosynthesis 2 ADP + phosphate + L-Glu + carbamoyl phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.3.5.5 Escherichia coli
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
6.3.5.5 2 ATP + L-glutamine + hydrogencarbonate + H2O = 2 ADP + phosphate + L-glutamate + carbamoyl phosphate pathway, relationship between mechanism and structure Escherichia coli
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.5.5 2 ATP + L-Gln + HCO3-
-
 Escherichia coli 2 ADP + phosphate + L-Glu + carbamoyl phosphate
-
 ir
6.3.5.5 2 ATP + L-Gln + HCO3- the product carbamoyl phosphate plays a critical role in both arginine and pyrimidine biosynthesis Escherichia coli 2 ADP + phosphate + L-Glu + carbamoyl phosphate
-
 ?
6.3.5.5 2 ATP + NH4+ + HCO3-
-
 Escherichia coli 2 ADP + phosphate + carbamoyl phosphate
-
 ir

Subunits

EC Number Subunits Comment Organism
6.3.5.5 heterodimer alpha,beta, the small subunit is able to catalyze the hydrolysis of glutamine, the large subunit catalyses the formation of carbamoyl phosphate using ammonia as a nitrogen source Escherichia coli