EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
5.4.99.7 | (6E)-10-Aza-10,11-dihydrosqualene-2,3-epoxide | IC50: 0.003 mM, at a protein concentration of 3 mg/ml | Candida albicans | |
5.4.99.7 | (6E)-10-Aza-10,11-dihydrosqualene-2,3-epoxide | IC50: 0.0048 mM, at a protein concentration of 5 mg/ml | Rattus norvegicus | |
5.4.99.7 | (6E)-10-Aza-10,11-dihydrosqualene-2,3-epoxide | IC50: 0.005 mM, at a protein concentration of 2 mg/ml | Saccharomyces cerevisiae | |
5.4.99.7 | (6E)-10-Aza-10,11-dihydrosqualene-2,3-epoxide | IC50: 0.005 mM, at a protein concentration of 1 mg/ml | Sus scrofa | |
5.4.99.7 | (6Z)-10-aza-10,11-dihydrosqualene-2,3-epoxide | IC50: above 0.1 mM, at a protein concentration of 3 mg/ml | Candida albicans | |
5.4.99.7 | (6Z)-10-aza-10,11-dihydrosqualene-2,3-epoxide | IC50: above 0.02 mM, at a protein concentration of 5 mg/ml | Rattus norvegicus | |
5.4.99.7 | (6Z)-10-aza-10,11-dihydrosqualene-2,3-epoxide | IC50: above 0.1 mM, at a protein concentration of 2 mg/ml | Saccharomyces cerevisiae | |
5.4.99.7 | 19-aza-18,19,22,23-tetrahydrosqualene-2,3-epoxide | IC50: 0.022 mM, protein concentration of 3 mg/ml | Candida albicans | |
5.4.99.7 | 19-aza-18,19,22,23-tetrahydrosqualene-2,3-epoxide | IC50: 0.0075 mM, protein concentration of 5 mg/ml | Rattus norvegicus | |
5.4.99.7 | 19-aza-18,19,22,23-tetrahydrosqualene-2,3-epoxide | IC50: 0.035 mM, at a protein concentration of 2 mg/ml | Saccharomyces cerevisiae | |
5.4.99.7 | 19-aza-18,19,22,23-tetrahydrosqualene-2,3-epoxide | IC50: 0.0015 mM | Sus scrofa | |
5.4.99.7 | 2-Aza-2,3-dihydrosqualene | 0.01 mM, 70% inhibition; IC50: 6.5 mM | Candida albicans | |
5.4.99.7 | 2-Aza-2,3-dihydrosqualene | 0.01 mM, 70% inhibition; IC50: 7.5 mM | Rattus norvegicus | |
5.4.99.7 | 2-Aza-2,3-dihydrosqualene | 0.01 mM, 70% inhibition; IC50: 10 mM | Saccharomyces cerevisiae | |
5.4.99.7 | 2-Aza-2,3-dihydrosqualene | IC50: 2.3 mM, pig microsomes. IC50: 0.15 mM, solubilized enzyme | Sus scrofa | |
5.4.99.7 | 2-Aza-2,3-dihydrosqualene N-oxide | IC50: 3.7 mM | Rattus norvegicus | |
5.4.99.7 | 2-Aza-2,3-dihydrosqualene N-oxide | IC50: 16 mM | Saccharomyces cerevisiae | |
5.4.99.7 | 2-Aza-2,3-dihydrosqualene N-oxide | IC50: 7 mM, pig microsomes. IC50: 3.3 mM, solubilized enzyme | Sus scrofa | |
5.4.99.7 | 22,23-epoxy-2-aza-2,3-dihydrosqualene-N-oxide | 0.01 mM, 14% inhibition | Rattus norvegicus | |
5.4.99.7 | 3-carboxy-4-nitrophenyldithio-1,1',2-tris-nor-squalene | - |
Saccharomyces cerevisiae | |
5.4.99.7 | 3-[Methyl-(4,8,13,17,21-pentamethyl-docosa-4,8,12,16,20-pentaenyl)-amino]-propan-1-ol | 0.01 mM, 2% inhibition | Rattus norvegicus | |
5.4.99.7 | azasqualene alcohol | 0.01 mM, 13% inhibition | Rattus norvegicus | |
5.4.99.7 | azasqualene alcohol N-oxide | IC50: 0.055 mM, at a protein concentration of 3 mg/ml | Candida albicans | |
5.4.99.7 | azasqualene alcohol N-oxide | IC50: 0.055 mM, at a protein concentration of 2 mg/ml | Saccharomyces cerevisiae | |
5.4.99.7 | diethyl-(4,8,13,17,21-pentamethyl-docosa-4,8,12,16,20-pentaenyl)-aminoxide | IC50: 1.5 mM | Rattus norvegicus | |
5.4.99.7 | diethyl-(4,8,13,17,21-pentamethyl-docosa-4,8,12,16,20-pentaenyl)-aminoxide | IC50: 14 mM | Saccharomyces cerevisiae | |
5.4.99.7 | Diethyl-(4,8,13,17,21-pentamethyl-docosa-4,8,12,16,20-pentaenyl)-ammonium | IC50: 3.2 mM | Rattus norvegicus | |
5.4.99.7 | Diethyl-(4,8,13,17,21-pentamethyl-docosa-4,8,12,16,20-pentaenyl)-ammonium | IC50: 12.5 mM | Saccharomyces cerevisiae | |
5.4.99.7 | Trimethyl-(4,8,13,17,21-pentamethyl-docosa-4,8,12,16,20-pentaenyl)-ammonium | IC50: 13.3 mM | Candida albicans | |
5.4.99.7 | Trimethyl-(4,8,13,17,21-pentamethyl-docosa-4,8,12,16,20-pentaenyl)-ammonium | IC50: 5.1 mM | Rattus norvegicus | |
5.4.99.7 | [19-(3,3-Dimethyl-oxiranyl)-4,8,13,17-tetramethyl-nonadeca-4,8,12,16-tetraenyl]-dimethyl-amine | 0.01 mM, 8% inhibition | Rattus norvegicus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
5.4.99.7 | microsome | - |
Rattus norvegicus | - |
- |
5.4.99.7 | microsome | - |
Sus scrofa | - |
- |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
5.4.99.7 | 78000 | - |
- |
Rattus norvegicus |
5.4.99.7 | 78000 | - |
- |
Saccharomyces cerevisiae |
5.4.99.7 | 78000 | - |
- |
Candida albicans |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
5.4.99.7 | Candida albicans | - |
- |
- |
5.4.99.7 | Canis lupus familiaris | - |
- |
- |
5.4.99.7 | Rattus norvegicus | - |
- |
- |
5.4.99.7 | Saccharomyces cerevisiae | - |
- |
- |
5.4.99.7 | Sus scrofa | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
5.4.99.7 | - |
Rattus norvegicus |
5.4.99.7 | - |
Sus scrofa |
5.4.99.7 | - |
Saccharomyces cerevisiae |
5.4.99.7 | - |
Canis lupus familiaris |
5.4.99.7 | - |
Candida albicans |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
5.4.99.7 | 0.0015 | - |
IC50: 0.0015 mM | Sus scrofa | 19-aza-18,19,22,23-tetrahydrosqualene-2,3-epoxide | |
5.4.99.7 | 0.003 | - |
IC50: 0.003 mM, at a protein concentration of 3 mg/ml | Candida albicans | (6E)-10-Aza-10,11-dihydrosqualene-2,3-epoxide | |
5.4.99.7 | 0.0048 | - |
IC50: 0.0048 mM, at a protein concentration of 5 mg/ml | Rattus norvegicus | (6E)-10-Aza-10,11-dihydrosqualene-2,3-epoxide | |
5.4.99.7 | 0.005 | - |
IC50: 0.005 mM, at a protein concentration of 1 mg/ml | Sus scrofa | (6E)-10-Aza-10,11-dihydrosqualene-2,3-epoxide | |
5.4.99.7 | 0.005 | - |
IC50: 0.005 mM, at a protein concentration of 2 mg/ml | Saccharomyces cerevisiae | (6E)-10-Aza-10,11-dihydrosqualene-2,3-epoxide | |
5.4.99.7 | 0.0075 | - |
IC50: 0.0075 mM, protein concentration of 5 mg/ml | Rattus norvegicus | 19-aza-18,19,22,23-tetrahydrosqualene-2,3-epoxide | |
5.4.99.7 | 0.02 | - |
IC50: above 0.02 mM, at a protein concentration of 5 mg/ml | Rattus norvegicus | (6Z)-10-aza-10,11-dihydrosqualene-2,3-epoxide | |
5.4.99.7 | 0.022 | - |
IC50: 0.022 mM, protein concentration of 3 mg/ml | Candida albicans | 19-aza-18,19,22,23-tetrahydrosqualene-2,3-epoxide | |
5.4.99.7 | 0.035 | - |
IC50: 0.035 mM, at a protein concentration of 2 mg/ml | Saccharomyces cerevisiae | 19-aza-18,19,22,23-tetrahydrosqualene-2,3-epoxide | |
5.4.99.7 | 0.055 | - |
IC50: 0.055 mM, at a protein concentration of 2 mg/ml | Saccharomyces cerevisiae | azasqualene alcohol N-oxide | |
5.4.99.7 | 0.055 | - |
IC50: 0.055 mM, at a protein concentration of 3 mg/ml | Candida albicans | azasqualene alcohol N-oxide | |
5.4.99.7 | 0.1 | - |
IC50: above 0.1 mM, at a protein concentration of 2 mg/ml | Saccharomyces cerevisiae | (6Z)-10-aza-10,11-dihydrosqualene-2,3-epoxide | |
5.4.99.7 | 0.1 | - |
IC50: above 0.1 mM, at a protein concentration of 3 mg/ml | Candida albicans | (6Z)-10-aza-10,11-dihydrosqualene-2,3-epoxide | |
5.4.99.7 | 0.15 | - |
IC50: 2.3 mM, pig microsomes. IC50: 0.15 mM, solubilized enzyme | Sus scrofa | 2-Aza-2,3-dihydrosqualene | |
5.4.99.7 | 1.5 | - |
IC50: 1.5 mM | Rattus norvegicus | diethyl-(4,8,13,17,21-pentamethyl-docosa-4,8,12,16,20-pentaenyl)-aminoxide | |
5.4.99.7 | 3.2 | - |
IC50: 3.2 mM | Rattus norvegicus | Diethyl-(4,8,13,17,21-pentamethyl-docosa-4,8,12,16,20-pentaenyl)-ammonium | |
5.4.99.7 | 3.3 | - |
IC50: 7 mM, pig microsomes. IC50: 3.3 mM, solubilized enzyme | Sus scrofa | 2-Aza-2,3-dihydrosqualene N-oxide | |
5.4.99.7 | 3.7 | - |
IC50: 3.7 mM | Rattus norvegicus | 2-Aza-2,3-dihydrosqualene N-oxide | |
5.4.99.7 | 5.1 | - |
IC50: 5.1 mM | Rattus norvegicus | Trimethyl-(4,8,13,17,21-pentamethyl-docosa-4,8,12,16,20-pentaenyl)-ammonium | |
5.4.99.7 | 6.5 | - |
IC50: 6.5 mM | Candida albicans | 2-Aza-2,3-dihydrosqualene | |
5.4.99.7 | 7.5 | - |
IC50: 7.5 mM | Rattus norvegicus | 2-Aza-2,3-dihydrosqualene | |
5.4.99.7 | 10 | - |
IC50: 10 mM | Saccharomyces cerevisiae | 2-Aza-2,3-dihydrosqualene | |
5.4.99.7 | 12.5 | - |
IC50: 12.5 mM | Saccharomyces cerevisiae | Diethyl-(4,8,13,17,21-pentamethyl-docosa-4,8,12,16,20-pentaenyl)-ammonium | |
5.4.99.7 | 13.3 | - |
IC50: 13.3 mM | Candida albicans | Trimethyl-(4,8,13,17,21-pentamethyl-docosa-4,8,12,16,20-pentaenyl)-ammonium | |
5.4.99.7 | 14 | - |
IC50: 14 mM | Saccharomyces cerevisiae | diethyl-(4,8,13,17,21-pentamethyl-docosa-4,8,12,16,20-pentaenyl)-aminoxide | |
5.4.99.7 | 16 | - |
IC50: 16 mM | Saccharomyces cerevisiae | 2-Aza-2,3-dihydrosqualene N-oxide |