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Literature summary extracted from

  • Cattel, L.; Ceruti, M.
    Inhibitors of 2,3-oxidosqualene cyclase as tools for studying the mechanism and function of the enzyme (1998), Crit. Rev. Biochem. Mol. Biol., 33, 353-373.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.4.99.7 (6E)-10-Aza-10,11-dihydrosqualene-2,3-epoxide IC50: 0.003 mM, at a protein concentration of 3 mg/ml Candida albicans
5.4.99.7 (6E)-10-Aza-10,11-dihydrosqualene-2,3-epoxide IC50: 0.0048 mM, at a protein concentration of 5 mg/ml Rattus norvegicus
5.4.99.7 (6E)-10-Aza-10,11-dihydrosqualene-2,3-epoxide IC50: 0.005 mM, at a protein concentration of 2 mg/ml Saccharomyces cerevisiae
5.4.99.7 (6E)-10-Aza-10,11-dihydrosqualene-2,3-epoxide IC50: 0.005 mM, at a protein concentration of 1 mg/ml Sus scrofa
5.4.99.7 (6Z)-10-aza-10,11-dihydrosqualene-2,3-epoxide IC50: above 0.1 mM, at a protein concentration of 3 mg/ml Candida albicans
5.4.99.7 (6Z)-10-aza-10,11-dihydrosqualene-2,3-epoxide IC50: above 0.02 mM, at a protein concentration of 5 mg/ml Rattus norvegicus
5.4.99.7 (6Z)-10-aza-10,11-dihydrosqualene-2,3-epoxide IC50: above 0.1 mM, at a protein concentration of 2 mg/ml Saccharomyces cerevisiae
5.4.99.7 19-aza-18,19,22,23-tetrahydrosqualene-2,3-epoxide IC50: 0.022 mM, protein concentration of 3 mg/ml Candida albicans
5.4.99.7 19-aza-18,19,22,23-tetrahydrosqualene-2,3-epoxide IC50: 0.0075 mM, protein concentration of 5 mg/ml Rattus norvegicus
5.4.99.7 19-aza-18,19,22,23-tetrahydrosqualene-2,3-epoxide IC50: 0.035 mM, at a protein concentration of 2 mg/ml Saccharomyces cerevisiae
5.4.99.7 19-aza-18,19,22,23-tetrahydrosqualene-2,3-epoxide IC50: 0.0015 mM Sus scrofa
5.4.99.7 2-Aza-2,3-dihydrosqualene 0.01 mM, 70% inhibition; IC50: 6.5 mM Candida albicans
5.4.99.7 2-Aza-2,3-dihydrosqualene 0.01 mM, 70% inhibition; IC50: 7.5 mM Rattus norvegicus
5.4.99.7 2-Aza-2,3-dihydrosqualene 0.01 mM, 70% inhibition; IC50: 10 mM Saccharomyces cerevisiae
5.4.99.7 2-Aza-2,3-dihydrosqualene IC50: 2.3 mM, pig microsomes. IC50: 0.15 mM, solubilized enzyme Sus scrofa
5.4.99.7 2-Aza-2,3-dihydrosqualene N-oxide IC50: 3.7 mM Rattus norvegicus
5.4.99.7 2-Aza-2,3-dihydrosqualene N-oxide IC50: 16 mM Saccharomyces cerevisiae
5.4.99.7 2-Aza-2,3-dihydrosqualene N-oxide IC50: 7 mM, pig microsomes. IC50: 3.3 mM, solubilized enzyme Sus scrofa
5.4.99.7 22,23-epoxy-2-aza-2,3-dihydrosqualene-N-oxide 0.01 mM, 14% inhibition Rattus norvegicus
5.4.99.7 3-carboxy-4-nitrophenyldithio-1,1',2-tris-nor-squalene
-
Saccharomyces cerevisiae
5.4.99.7 3-[Methyl-(4,8,13,17,21-pentamethyl-docosa-4,8,12,16,20-pentaenyl)-amino]-propan-1-ol 0.01 mM, 2% inhibition Rattus norvegicus
5.4.99.7 azasqualene alcohol 0.01 mM, 13% inhibition Rattus norvegicus
5.4.99.7 azasqualene alcohol N-oxide IC50: 0.055 mM, at a protein concentration of 3 mg/ml Candida albicans
5.4.99.7 azasqualene alcohol N-oxide IC50: 0.055 mM, at a protein concentration of 2 mg/ml Saccharomyces cerevisiae
5.4.99.7 diethyl-(4,8,13,17,21-pentamethyl-docosa-4,8,12,16,20-pentaenyl)-aminoxide IC50: 1.5 mM Rattus norvegicus
5.4.99.7 diethyl-(4,8,13,17,21-pentamethyl-docosa-4,8,12,16,20-pentaenyl)-aminoxide IC50: 14 mM Saccharomyces cerevisiae
5.4.99.7 Diethyl-(4,8,13,17,21-pentamethyl-docosa-4,8,12,16,20-pentaenyl)-ammonium IC50: 3.2 mM Rattus norvegicus
5.4.99.7 Diethyl-(4,8,13,17,21-pentamethyl-docosa-4,8,12,16,20-pentaenyl)-ammonium IC50: 12.5 mM Saccharomyces cerevisiae
5.4.99.7 Trimethyl-(4,8,13,17,21-pentamethyl-docosa-4,8,12,16,20-pentaenyl)-ammonium IC50: 13.3 mM Candida albicans
5.4.99.7 Trimethyl-(4,8,13,17,21-pentamethyl-docosa-4,8,12,16,20-pentaenyl)-ammonium IC50: 5.1 mM Rattus norvegicus
5.4.99.7 [19-(3,3-Dimethyl-oxiranyl)-4,8,13,17-tetramethyl-nonadeca-4,8,12,16-tetraenyl]-dimethyl-amine 0.01 mM, 8% inhibition Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
5.4.99.7 microsome
-
Rattus norvegicus
-
-
5.4.99.7 microsome
-
Sus scrofa
-
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
5.4.99.7 78000
-
-
Rattus norvegicus
5.4.99.7 78000
-
-
Saccharomyces cerevisiae
5.4.99.7 78000
-
-
Candida albicans

Organism

EC Number Organism UniProt Comment Textmining
5.4.99.7 Candida albicans
-
-
-
5.4.99.7 Canis lupus familiaris
-
-
-
5.4.99.7 Rattus norvegicus
-
-
-
5.4.99.7 Saccharomyces cerevisiae
-
-
-
5.4.99.7 Sus scrofa
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
5.4.99.7
-
Rattus norvegicus
5.4.99.7
-
Sus scrofa
5.4.99.7
-
Saccharomyces cerevisiae
5.4.99.7
-
Canis lupus familiaris
5.4.99.7
-
Candida albicans

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
5.4.99.7 0.0015
-
IC50: 0.0015 mM Sus scrofa 19-aza-18,19,22,23-tetrahydrosqualene-2,3-epoxide
5.4.99.7 0.003
-
IC50: 0.003 mM, at a protein concentration of 3 mg/ml Candida albicans (6E)-10-Aza-10,11-dihydrosqualene-2,3-epoxide
5.4.99.7 0.0048
-
IC50: 0.0048 mM, at a protein concentration of 5 mg/ml Rattus norvegicus (6E)-10-Aza-10,11-dihydrosqualene-2,3-epoxide
5.4.99.7 0.005
-
IC50: 0.005 mM, at a protein concentration of 1 mg/ml Sus scrofa (6E)-10-Aza-10,11-dihydrosqualene-2,3-epoxide
5.4.99.7 0.005
-
IC50: 0.005 mM, at a protein concentration of 2 mg/ml Saccharomyces cerevisiae (6E)-10-Aza-10,11-dihydrosqualene-2,3-epoxide
5.4.99.7 0.0075
-
IC50: 0.0075 mM, protein concentration of 5 mg/ml Rattus norvegicus 19-aza-18,19,22,23-tetrahydrosqualene-2,3-epoxide
5.4.99.7 0.02
-
IC50: above 0.02 mM, at a protein concentration of 5 mg/ml Rattus norvegicus (6Z)-10-aza-10,11-dihydrosqualene-2,3-epoxide
5.4.99.7 0.022
-
IC50: 0.022 mM, protein concentration of 3 mg/ml Candida albicans 19-aza-18,19,22,23-tetrahydrosqualene-2,3-epoxide
5.4.99.7 0.035
-
IC50: 0.035 mM, at a protein concentration of 2 mg/ml Saccharomyces cerevisiae 19-aza-18,19,22,23-tetrahydrosqualene-2,3-epoxide
5.4.99.7 0.055
-
IC50: 0.055 mM, at a protein concentration of 2 mg/ml Saccharomyces cerevisiae azasqualene alcohol N-oxide
5.4.99.7 0.055
-
IC50: 0.055 mM, at a protein concentration of 3 mg/ml Candida albicans azasqualene alcohol N-oxide
5.4.99.7 0.1
-
IC50: above 0.1 mM, at a protein concentration of 2 mg/ml Saccharomyces cerevisiae (6Z)-10-aza-10,11-dihydrosqualene-2,3-epoxide
5.4.99.7 0.1
-
IC50: above 0.1 mM, at a protein concentration of 3 mg/ml Candida albicans (6Z)-10-aza-10,11-dihydrosqualene-2,3-epoxide
5.4.99.7 0.15
-
IC50: 2.3 mM, pig microsomes. IC50: 0.15 mM, solubilized enzyme Sus scrofa 2-Aza-2,3-dihydrosqualene
5.4.99.7 1.5
-
IC50: 1.5 mM Rattus norvegicus diethyl-(4,8,13,17,21-pentamethyl-docosa-4,8,12,16,20-pentaenyl)-aminoxide
5.4.99.7 3.2
-
IC50: 3.2 mM Rattus norvegicus Diethyl-(4,8,13,17,21-pentamethyl-docosa-4,8,12,16,20-pentaenyl)-ammonium
5.4.99.7 3.3
-
IC50: 7 mM, pig microsomes. IC50: 3.3 mM, solubilized enzyme Sus scrofa 2-Aza-2,3-dihydrosqualene N-oxide
5.4.99.7 3.7
-
IC50: 3.7 mM Rattus norvegicus 2-Aza-2,3-dihydrosqualene N-oxide
5.4.99.7 5.1
-
IC50: 5.1 mM Rattus norvegicus Trimethyl-(4,8,13,17,21-pentamethyl-docosa-4,8,12,16,20-pentaenyl)-ammonium
5.4.99.7 6.5
-
IC50: 6.5 mM Candida albicans 2-Aza-2,3-dihydrosqualene
5.4.99.7 7.5
-
IC50: 7.5 mM Rattus norvegicus 2-Aza-2,3-dihydrosqualene
5.4.99.7 10
-
IC50: 10 mM Saccharomyces cerevisiae 2-Aza-2,3-dihydrosqualene
5.4.99.7 12.5
-
IC50: 12.5 mM Saccharomyces cerevisiae Diethyl-(4,8,13,17,21-pentamethyl-docosa-4,8,12,16,20-pentaenyl)-ammonium
5.4.99.7 13.3
-
IC50: 13.3 mM Candida albicans Trimethyl-(4,8,13,17,21-pentamethyl-docosa-4,8,12,16,20-pentaenyl)-ammonium
5.4.99.7 14
-
IC50: 14 mM Saccharomyces cerevisiae diethyl-(4,8,13,17,21-pentamethyl-docosa-4,8,12,16,20-pentaenyl)-aminoxide
5.4.99.7 16
-
IC50: 16 mM Saccharomyces cerevisiae 2-Aza-2,3-dihydrosqualene N-oxide