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Literature summary extracted from

  • Terjesen, B.F.; Ronnestad, I.; Norberg, B.; Anderson, P.M.
    Detection and basic properties of carbamoyl phosphate synthetase III during teleost ontogeny: a case study in the Atlantic halibut (Hippoglossus hippoglossus L.) (2000), Comp. Biochem. Physiol. B, 126, 521-535.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
6.3.5.5 N-acetyl-L-glutamate
-
 Galeus melastomus
6.3.5.5 N-acetyl-L-glutamate activation of CPS III, not CPS II Hippoglossus hippoglossus

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.3.5.5 additional information not: UTP Galeus melastomus
6.3.5.5 UTP when L-glutamine is the substrate: 94% inhibition of enzyme activity peak 1: CPS II, 6% inhibition of enzyme activity peak 2: CPS III, when NH4Cl is the substrate: 100% inhibition of enzyme activity peak 1: CPS II, 46% inhibition of enzyme activity peak 2: CPS III Hippoglossus hippoglossus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
6.3.5.5 160000 170000 gel filtration, CPS III Hippoglossus hippoglossus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.3.5.5 2 ATP + L-Gln + HCO3- Hippoglossus hippoglossus enzyme catalyses the first step of urea cycle in fish 2 ADP + phosphate + L-Glu + carbamoyl phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.3.5.5 Galeus melastomus
-
 Blackmous catshark
-
6.3.5.5 Hippoglossus hippoglossus
-
 atlantic halibut, yolk-sac larvae and adult, two enzymes: CPS II and CPS III
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Storage Stability

EC Number Storage Stability Organism
6.3.5.5 -80°C, stable, 6 months Hippoglossus hippoglossus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.5.5 2 ATP + L-Gln + HCO3-
-
 Hippoglossus hippoglossus 2 ADP + phosphate + L-Glu + carbamoyl phosphate
-
 ?
6.3.5.5 2 ATP + L-Gln + HCO3-
-
 Galeus melastomus 2 ADP + phosphate + L-Glu + carbamoyl phosphate
-
 ?
6.3.5.5 2 ATP + L-Gln + HCO3- enzyme catalyses the first step of urea cycle in fish Hippoglossus hippoglossus 2 ADP + phosphate + L-Glu + carbamoyl phosphate
-
 ?
6.3.5.5 2 ATP + NH4+ + HCO3- CPS III shows low activity in comparison to L-glutamine Hippoglossus hippoglossus 2 ADP + phosphate + carbamoyl phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.3.5.5 carbamoyl phosphate synthetase III
-
 Hippoglossus hippoglossus
6.3.5.5 carbamoyl phosphate synthetase III
-
 Galeus melastomus
6.3.5.5 CPS III
-
 Hippoglossus hippoglossus
6.3.5.5 CPS III
-
 Galeus melastomus