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Literature summary extracted from
- Bromelain: biochemistry, pharmacology and medical use (2001), Cell. Mol. Life Sci., 58, 1234-1245.
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 3.4.22.33 | medicine | bromelain can be used as a phytotherapy agent in several aspects, overview | Ananas comosus |
| 3.4.22.33 | pharmacology | use as additive to prevent lymphedema by reducing lymphocongestion, detritus, viscosity of the exsudate and stimulation of phagocytosis of associated leukocytes, use as additive for radiotherapy and surgery due to wound healing effect and reductive effect on inflammation and edema, use as additives for chemotherapy due to inhibitory effects on malignant growth of tumor cells | Ananas comosus |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 3.4.22.33 | 23000 | - |
x * 23000, SDS-PAGE | Ananas comosus |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.22.33 | additional information | Ananas comosus | bromelain has a profound immunmodulatory effect, overview, bromelain affects blood coagulation, fibrinolysis, and platelet functions, mechanism, overview | ? | - |
? |  |
| 3.4.22.33 | protein + H2O | Ananas comosus | broad substrate specificity | peptides | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.22.33 | Ananas comosus | - |
mainly var. Cayenne | - |
Posttranslational Modification
| EC Number | Posttranslational Modification | Comment | Organism |
|---|---|---|---|
| 3.4.22.33 | no glycoprotein | - |
Ananas comosus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.22.33 | fruit | immature | Ananas comosus | - |
| 3.4.22.33 | juice | - |
Ananas comosus | - |
| 3.4.22.33 | additional information | bromelain is a crude extract containing a complex mixture of several components, such as different thiol-endopeptidases, phosphatases, glucosidases, peroxidases, cellulases, glycoproteins and carbohydrates, as well as several proteinase inhibitors | Ananas comosus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.22.33 | bromelain + H2O | rapid self-digestion in aqueous solution, can be prevented by addition of alpha2-macroglobulin | Ananas comosus | ? | - |
? | |
| 3.4.22.33 | casein + H2O | - |
Ananas comosus | ? | - |
? | |
| 3.4.22.33 | Gelatin + H2O | - |
Ananas comosus | ? | - |
? | |
| 3.4.22.33 | additional information | bromelain has a profound immunmodulatory effect, overview, bromelain affects blood coagulation, fibrinolysis, and platelet functions, mechanism, overview | Ananas comosus | ? | - |
? | |
| 3.4.22.33 | protein + H2O | broad substrate specificity | Ananas comosus | peptides | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 3.4.22.33 | ? | x * 23000, SDS-PAGE | Ananas comosus |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.22.33 | Bromelain | - |
Ananas comosus |
| 3.4.22.33 | Bromelin | - |
Ananas comosus |
| 3.4.22.33 | More | c.f. stem bromelain, enzyme belongs to the papain superfamily | Ananas comosus |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.4.22.33 | 5.5 | 8 | - |
Ananas comosus |
pI Value
| EC Number | Organism | Comment | pI Value Maximum | pI Value |
|---|---|---|---|---|
| 3.4.22.33 | Ananas comosus | isoelectric focusing | 4.7 | 4.6 |
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