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Literature summary extracted from

  • Ramos, K.L.; Colquhoun, A.
    Evidence for the involvement of polyunsaturated fatty acids in the regulation of long-chain acyl CoA thioesterases and peroxisome proliferation in rat carcinosarcoma (2001), Cell Biochem. Funct., 19, 1-9.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.2.2 polyunsaturated fatty acids diet rich in polyunsaturated fatty acids increase in enzyme activity in Walker 256 tumour along with an increase in peroxisome number in the tissue Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.2.2 peroxisome peroxisomal isozyme PTE-I Rattus norvegicus 5777
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.2.2 oleoyl-CoA + H2O Rattus norvegicus
-
 CoA + oleate
-
 ?
3.1.2.2 palmitoyl-CoA + H2O Rattus norvegicus
-
 CoA + palmitate
-
 ?
3.1.2.2 stearoyl-CoA + H2O Rattus norvegicus
-
 CoA + stearate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.2.2 Rattus norvegicus
-
 male Wistar rats, isozymes CTE-I, MTE-I, and PTE-I
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.2.2 carcinosarcoma cell
-
 Rattus norvegicus
-
3.1.2.2 LLC-WRC 256 cell cell line derived from Walker 256 tumour Rattus norvegicus
-
3.1.2.2 Walker carcinoma 256 cell only peroxisomal isozyme, no mitochondrial and cytosolic isozyme activity Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.1.2.2 additional information
-
 effects of diet conditions on enzyme activity Rattus norvegicus
3.1.2.2 0.000048 0.000058 Walker 256 tumour, normal chow, substrate stearoyl-CoA Rattus norvegicus
3.1.2.2 0.000072
-
 Walker 256 tumour, normal chow, substrate palmitoleoyl-CoA Rattus norvegicus
3.1.2.2 0.000095 0.000111 Walker 256 tumour, normal chow, substrate oleoyl-CoA Rattus norvegicus
3.1.2.2 0.000133 0.000142 Walker 256 tumour, normal chow, substrate palmitoyl-CoA Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.2.2 oleoyl-CoA + H2O
-
 Rattus norvegicus CoA + oleate
-
 ?
3.1.2.2 palmitoyl-CoA + H2O
-
 Rattus norvegicus CoA + palmitate
-
 ?
3.1.2.2 stearoyl-CoA + H2O
-
 Rattus norvegicus CoA + stearate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.2.2 long-chain acyl CoA thioesterase
-
 Rattus norvegicus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.2.2 25
-
 assay at Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.2.2 7.4
-
 assay at Rattus norvegicus